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Most cancers exhibited moderate granular cytoplasmic positivity. Colorectal along with a few testis, urothelial, stomach, head and neck cancers showed strong positivity. Several cases of renal cell carcinomas and hepatocellular carcinomas were weakly stained or negative.
GENE INFORMATION
Gene name
PEX26 (HGNC Symbol)
Synonyms
FLJ20695
Description
Peroxisomal biogenesis factor 26 (HGNC Symbol)
Entrez gene summary
This gene belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2010]
Q7Z412 [Direct mapping] Peroxisome assembly protein 26
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Transporters Primary Active Transporters Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Q7Z412 [Direct mapping] Peroxisome assembly protein 26
Show all
Transporters Primary Active Transporters Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
