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DDX3X

CANCER ATLAS

Gene description

 DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked

Protein class

 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001648
HPA005631
HPA059585

GENE INFORMATION

Gene name

 DDX3X (HGNC Symbol)

Synonyms

 DBX, DDX14, DDX3, HLP2

Description

 DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Chromosome

 X

Cytoband

 p11.4

Chromosome location (bp)

 41333348 - 41364472

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000215301 (version 83.38)

Entrez gene

 1654

UniProt

 O00571 (UniProt - Evidence at protein level)

neXtProt

 NX_O00571

Antibodypedia

 DDX3X antibodies

PROTEIN BROWSER
DDX3X-001
DDX3X-005
DDX3X-012
DDX3X-014
DDX3X-017
DDX3X-020
DDX3X-021
DDX3X-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DDX3X-001
ENSP00000382840
ENST00000399959
O00571 [Direct mapping]
ATP-dependent RNA helicase DDX3X
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003924 [GTPase activity]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006351 [transcription, DNA-templated]
GO:0006413 [translational initiation]
GO:0007059 [chromosome segregation]
GO:0008134 [transcription factor binding]
GO:0008143 [poly(A) binding]
GO:0008190 [eukaryotic initiation factor 4E binding]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0009615 [response to virus]
GO:0010494 [cytoplasmic stress granule]
GO:0010501 [RNA secondary structure unwinding]
GO:0010628 [positive regulation of gene expression]
GO:0016032 [viral process]
GO:0016607 [nuclear speck]
GO:0016887 [ATPase activity]
GO:0017111 [nucleoside-triphosphatase activity]
GO:0017148 [negative regulation of translation]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0031333 [negative regulation of protein complex assembly]
GO:0031369 [translation initiation factor binding]
GO:0032508 [DNA duplex unwinding]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034063 [stress granule assembly]
GO:0035556 [intracellular signal transduction]
GO:0035613 [RNA stem-loop binding]
GO:0042256 [mature ribosome assembly]
GO:0043024 [ribosomal small subunit binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043273 [CTPase activity]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045727 [positive regulation of translation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045948 [positive regulation of translational initiation]
GO:0048027 [mRNA 5'-UTR binding]
GO:0070062 [extracellular exosome]
GO:0071243 [cellular response to arsenic-containing substance]
GO:0071470 [cellular response to osmotic stress]
GO:0071651 [positive regulation of chemokine (C-C motif) ligand 5 production]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
 662 aa
73.2 kDa 		No 0
DDX3X-005
ENSP00000414281
ENST00000441189
B4DLA0 [Direct mapping]
ATP-dependent RNA helicase DDX3X; cDNA FLJ55031, highly similar to ATP-dependent RNA helicase DDX3X (EC 3.6.1.-)
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004386 [helicase activity]
GO:0006413 [translational initiation]
Show all
 139 aa
15 kDa 		No 0
DDX3X-012
ENSP00000479790
ENST00000611968
A0A087WVZ1 [Direct mapping]
ATP-dependent RNA helicase DDX3X
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006413 [translational initiation]
Show all
 138 aa
14.7 kDa 		No 0
DDX3X-014
ENSP00000487224
ENST00000629496
O00571 [Direct mapping]
ATP-dependent RNA helicase DDX3X
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003924 [GTPase activity]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006351 [transcription, DNA-templated]
GO:0006413 [translational initiation]
GO:0007059 [chromosome segregation]
GO:0008134 [transcription factor binding]
GO:0008143 [poly(A) binding]
GO:0008190 [eukaryotic initiation factor 4E binding]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0009615 [response to virus]
GO:0010494 [cytoplasmic stress granule]
GO:0010501 [RNA secondary structure unwinding]
GO:0010628 [positive regulation of gene expression]
GO:0016032 [viral process]
GO:0016607 [nuclear speck]
GO:0016887 [ATPase activity]
GO:0017111 [nucleoside-triphosphatase activity]
GO:0017148 [negative regulation of translation]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0031333 [negative regulation of protein complex assembly]
GO:0031369 [translation initiation factor binding]
GO:0032508 [DNA duplex unwinding]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034063 [stress granule assembly]
GO:0035556 [intracellular signal transduction]
GO:0035613 [RNA stem-loop binding]
GO:0042256 [mature ribosome assembly]
GO:0043024 [ribosomal small subunit binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043273 [CTPase activity]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045727 [positive regulation of translation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045948 [positive regulation of translational initiation]
GO:0048027 [mRNA 5'-UTR binding]
GO:0070062 [extracellular exosome]
GO:0071243 [cellular response to arsenic-containing substance]
GO:0071470 [cellular response to osmotic stress]
GO:0071651 [positive regulation of chemokine (C-C motif) ligand 5 production]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
 662 aa
73.2 kDa 		No 0
DDX3X-017
ENSP00000486306
ENST00000625837
A0A0D9SF53 [Direct mapping]
ATP-dependent RNA helicase DDX3X
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004386 [helicase activity]
GO:0005524 [ATP binding]
GO:0006413 [translational initiation]
Show all
 733 aa
81.5 kDa 		No 0
DDX3X-020
ENSP00000486443
ENST00000626301
A0A0D9SFB3 [Direct mapping]
ATP-dependent RNA helicase DDX3X
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0004386 [helicase activity]
GO:0005524 [ATP binding]
GO:0006413 [translational initiation]
Show all
 640 aa
70.8 kDa 		No 0
DDX3X-021
ENSP00000488854
ENST00000631641
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 164 aa
17.8 kDa 		No 0
DDX3X-201
ENSP00000392494
ENST00000457138
O00571 [Direct mapping]
ATP-dependent RNA helicase DDX3X
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003924 [GTPase activity]
GO:0004003 [ATP-dependent DNA helicase activity]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006351 [transcription, DNA-templated]
GO:0006413 [translational initiation]
GO:0007059 [chromosome segregation]
GO:0008134 [transcription factor binding]
GO:0008143 [poly(A) binding]
GO:0008190 [eukaryotic initiation factor 4E binding]
GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors]
GO:0009615 [response to virus]
GO:0010494 [cytoplasmic stress granule]
GO:0010501 [RNA secondary structure unwinding]
GO:0010628 [positive regulation of gene expression]
GO:0016032 [viral process]
GO:0016607 [nuclear speck]
GO:0016887 [ATPase activity]
GO:0017111 [nucleoside-triphosphatase activity]
GO:0017148 [negative regulation of translation]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0030307 [positive regulation of cell growth]
GO:0030308 [negative regulation of cell growth]
GO:0031333 [negative regulation of protein complex assembly]
GO:0031369 [translation initiation factor binding]
GO:0032508 [DNA duplex unwinding]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034063 [stress granule assembly]
GO:0035556 [intracellular signal transduction]
GO:0035613 [RNA stem-loop binding]
GO:0042256 [mature ribosome assembly]
GO:0043024 [ribosomal small subunit binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043273 [CTPase activity]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045727 [positive regulation of translation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045948 [positive regulation of translational initiation]
GO:0048027 [mRNA 5'-UTR binding]
GO:0070062 [extracellular exosome]
GO:0071243 [cellular response to arsenic-containing substance]
GO:0071470 [cellular response to osmotic stress]
GO:0071651 [positive regulation of chemokine (C-C motif) ligand 5 production]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
 646 aa
71.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.