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VPS16

CANCER ATLAS

Gene description

 Vacuolar protein sorting 16 homolog (S. cerevisiae)

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA043229
HPA048661

GENE INFORMATION

Gene name

 VPS16

Synonyms

Description

 Vacuolar protein sorting 16 homolog (S. cerevisiae) (HGNC Symbol)

Entrez gene summary

 Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 2840703 - 2866732

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000215305 (version 83.38)

Entrez gene

 64601

UniProt

 Q9H269 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H269

Antibodypedia

 VPS16 antibodies

PROTEIN BROWSER
VPS16-001
VPS16-003
VPS16-004
VPS16-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VPS16-001
ENSP00000369810
ENST00000380445
Q9H269 [Direct mapping]
Vacuolar protein sorting-associated protein 16 homolog
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005776 [autophagosome]
GO:0005884 [actin filament]
GO:0006886 [intracellular protein transport]
GO:0007033 [vacuole organization]
GO:0008333 [endosome to lysosome transport]
GO:0016197 [endosomal transport]
GO:0030136 [clathrin-coated vesicle]
GO:0030424 [axon]
GO:0030897 [HOPS complex]
GO:0031902 [late endosome membrane]
GO:0032889 [regulation of vacuole fusion, non-autophagic]
GO:0035542 [regulation of SNARE complex assembly]
GO:0043025 [neuronal cell body]
GO:0046718 [viral entry into host cell]
GO:0051015 [actin filament binding]
GO:0055037 [recycling endosome]
GO:0097352 [autophagosome maturation]
Show all
 839 aa
94.7 kDa 		No 0
VPS16-003
ENSP00000369836
ENST00000380469
Q9H269 [Direct mapping]
Vacuolar protein sorting-associated protein 16 homolog
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005776 [autophagosome]
GO:0006886 [intracellular protein transport]
GO:0008333 [endosome to lysosome transport]
GO:0016197 [endosomal transport]
GO:0030136 [clathrin-coated vesicle]
GO:0030897 [HOPS complex]
GO:0031902 [late endosome membrane]
GO:0032889 [regulation of vacuole fusion, non-autophagic]
GO:0035542 [regulation of SNARE complex assembly]
GO:0055037 [recycling endosome]
GO:0097352 [autophagosome maturation]
Show all
 695 aa
78.3 kDa 		No 0
VPS16-004
ENSP00000409840
ENST00000417508
Q5JUB0 [Direct mapping]
Vacuolar protein sorting-associated protein 16 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0006886 [intracellular protein transport]
GO:0007033 [vacuole organization]
GO:0016197 [endosomal transport]
GO:0032889 [regulation of vacuole fusion, non-autophagic]
GO:0035542 [regulation of SNARE complex assembly]
Show all
 227 aa
25.1 kDa 		No 0
VPS16-005
ENSP00000417031
ENST00000453689
Q5JUA9 [Direct mapping]
Vacuolar protein sorting-associated protein 16 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005737 [cytoplasm]
GO:0006886 [intracellular protein transport]
GO:0007033 [vacuole organization]
GO:0016197 [endosomal transport]
GO:0032889 [regulation of vacuole fusion, non-autophagic]
GO:0035542 [regulation of SNARE complex assembly]
Show all
 274 aa
30.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.