Tissue expression of HMX1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HMX1
Gene description	H6 family homeobox 1
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Tissue enhanced (testis, hypothalamus)
FANTOM5:	Tissue enriched (retina)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis, hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (retina)

GENE INFORMATION
Gene name	HMX1 (HGNC Symbol)
Synonyms	H6, NKX5-3
Description	H6 family homeobox 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor that belongs to the H6 family of homeobox proteins. This protein can bind a 5'-CAAG-3' core DNA sequence, and it is involved in the development of craniofacial structures. Mutations in this gene cause oculoauricular syndrome, a disorder of the eye and external ear. [provided by RefSeq, Oct 2009]
Chromosome	4
Cytoband	p16.1
Chromosome location (bp)	8846076 - 8871817
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000215612 (version 83.38)
Entrez gene	3166
UniProt	Q9NP08 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NP08
Antibodypedia	HMX1 antibodies

PROTEIN BROWSER

HMX1-001	HMX1-002	HMX1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HMX1-001 ENSP00000383516 ENST00000400677	Q9NP08 [Direct mapping] Homeobox protein HMX1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Disease related genes Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	348 aa 36.2 kDa	No	0
HMX1-002 ENSP00000446997 ENST00000506970	F1T0J4 [Direct mapping] Homeobox protein HMX1 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] Show all	190 aa 20 kDa	No	0
HMX1-201 ENSP00000479086 ENST00000617742	A0A087WV14 [Direct mapping] Homeobox protein HMX1 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	373 aa 39.3 kDa	No	0