Tissue expression of CELA2B - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CELA2B
Gene description	Chymotrypsin-like elastase family, member 2B
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (pancreas)
GTEx:	Tissue enriched (pancreas)
FANTOM5:	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pancreas)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pancreas)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pancreas)

GENE INFORMATION
Gene name	CELA2B (HGNC Symbol)
Synonyms	ELA2B, RP11-265F14.2
Description	Chymotrypsin-like elastase family, member 2B (HGNC Symbol)
Entrez gene summary	Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.21
Chromosome location (bp)	15465909 - 15491400
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000215704 (version 83.38)
Entrez gene	51032
UniProt	P08218 (UniProt - Evidence at transcript level)
neXtProt	NX_P08218
Antibodypedia	CELA2B antibodies

PROTEIN BROWSER

CELA2B-001	CELA2B-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CELA2B-001 ENSP00000365075 ENST00000375910	P08218 [Direct mapping] Chymotrypsin-like elastase family member 2B Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006508 [proteolysis] Show all	269 aa 28.8 kDa	Yes	0
CELA2B-002 ENSP00000399811 ENST00000422901	Q5JRU4 [Direct mapping] Chymotrypsin-like elastase family member 2B Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	126 aa 13.7 kDa	No	0