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Most cancer cells displayed weak to moderate cytoplasmic staining. Several colorectal cancers along with a few ovarian, stomach, liver and pancreatic cancers showed strong immunoreactivity. Several lymphomas, testis, renal and cervical cancers were negative.
Several renal cancers exhibited moderate cytoplasmic, nuclear and membranous positivity. A few cases of hepatocellular and urothelial carcinomas showed moderate cytoplasmic and nuclear staining. Remaining cancer tissues were negative.
Several cases of squamous cell carcinomas of lung, cervix, skin, papillary adenocarcinomas of thyroid, ovarian, colorectal and pancreatic cancers showed moderate to strong membranous staining. Remaining cancer tissues were weakly stained or negative.
A single case of squamous cell carcinoma of head and neck cancer showed moderate nuclear immunoreactivity. Rare cases of endometrial, thyroid and pancreatic cancers exhibited weak nuclear staining. Remaining cancer tissues were negative.
Most liver cancers, lobular carcinomas of breast and adenocarcinomas of lung along with few stomach cancers showed moderate cytoplasmic immunoreactivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
NBPF1 (HGNC Symbol)
Synonyms
FLJ20719, KIAA1693
Description
Neuroblastoma breakpoint family, member 1 (HGNC Symbol)
