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Cancer tissues displayed weak to moderate cytoplasmic staining with additional nuclear positivity in several tissues. Rare cases of carcinoids, lymphomas, breast and liver cancer were strongly stained. Several cases of colorectal, endometrial, lung, skin and testicular cancers were negative.
GENE INFORMATION
Gene name
OR6B1 (HGNC Symbol)
Synonyms
OR7-3
Description
Olfactory receptor, family 6, subfamily B, member 1 (HGNC Symbol)
Entrez gene summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
