Cell atlas - CEBPD - The Human Protein Atlas

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CEBPD

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CEBPD
Gene description	CCAAT/enhancer binding protein (C/EBP), delta
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (NB-4, SiHa, BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA067581
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NB-4, SiHa, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA067581	BJ	Nucleoplasm
	HPA067581	SiHa	Nucleoplasm	Intensity
	HPA067581	U-2 OS	No staining

GENE INFORMATION
Gene name	CEBPD (HGNC Symbol)
Synonyms	C/EBP-delta, CELF, CRP3, NF-IL6-beta
Description	CCAAT/enhancer binding protein (C/EBP), delta (HGNC Symbol)
Entrez gene summary	The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]
Chromosome	8
Cytoband	q11.21
Chromosome location (bp)	47736909 - 47739086
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000221869 (version 83.38)
Entrez gene	1052
UniProt	P49716 (UniProt - Evidence at protein level)
neXtProt	NX_P49716
Antibodypedia	CEBPD antibodies

PROTEIN BROWSER

CEBPD-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEBPD-001 ENSP00000386165 ENST00000408965	P49716 [Direct mapping] CCAAT/enhancer-binding protein delta Show all	Phobius predicted secreted proteins Predicted intracellular proteins Transcription factors Basic domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	269 aa 28.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.