Cell atlas - SLC12A8 - The Human Protein Atlas

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SLC12A8

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SLC12A8
Gene description	Solute carrier family 12, member 8
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (U-2197)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA031123
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2197) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031123	A-431	Nucleoplasm
	HPA031123	U-2 OS	Nucleoplasm
	HPA031123	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	SLC12A8 (HGNC Symbol)
Synonyms	CCC9
Description	Solute carrier family 12, member 8 (HGNC Symbol)
Entrez gene summary	This gene is thought to be a candidate for psoriasis susceptibility. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2010]
Chromosome	3
Cytoband	q21.2
Chromosome location (bp)	125082636 - 125212864
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000221955 (version 83.38)
Entrez gene	84561
UniProt	A0AV02 (UniProt - Evidence at transcript level)
neXtProt	NX_A0AV02
Antibodypedia	SLC12A8 antibodies

PROTEIN BROWSER

SLC12A8-001	SLC12A8-003	SLC12A8-004	SLC12A8-014	SLC12A8-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC12A8-001 ENSP00000377112 ENST00000393469	A0AV02 [Direct mapping] Solute carrier family 12 member 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006884 [cell volume homeostasis] GO:0010107 [potassium ion import] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0022820 [potassium ion symporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	714 aa 78.2 kDa	No	>9
SLC12A8-003 ENSP00000415713 ENST00000430155	A0AV02 [Direct mapping] Solute carrier family 12 member 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006884 [cell volume homeostasis] GO:0010107 [potassium ion import] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0022820 [potassium ion symporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	515 aa 56.2 kDa	No	4
SLC12A8-004 ENSP00000418783 ENST00000469902	A0AV02 [Direct mapping] Solute carrier family 12 member 8 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006884 [cell volume homeostasis] GO:0010107 [potassium ion import] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0022820 [potassium ion symporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	714 aa 78.2 kDa	No	>9
SLC12A8-014 ENSP00000420197 ENST00000479826	H7C5L2 [Direct mapping] Solute carrier family 12 member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	207 aa 23 kDa	No	3
SLC12A8-015 ENSP00000418636 ENST00000462437	C9IZN2 [Direct mapping] Solute carrier family 12 member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	112 aa 11.6 kDa	No	3

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.