Tissue expression of FADS3 - Summary - The Human Protein Atlas

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FADS3

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FADS3
Gene description	Fatty acid desaturase 3
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Expressed in several tissues, including smooth muscle.

DATA RELIABILITY
Data reliability description	Pending external verification. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA045224
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	FADS3 (HGNC Symbol)
Synonyms	CYB5RP, LLCDL3
Description	Fatty acid desaturase 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members FADS1 and FADS2 at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	61873519 - 61892051
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000221968 (version 83.38)
Entrez gene	3995
UniProt	Q9Y5Q0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y5Q0
Antibodypedia	FADS3 antibodies

PROTEIN BROWSER

FADS3-001	FADS3-002	FADS3-006	FADS3-008	FADS3-009	FADS3-012	FADS3-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FADS3-001 ENSP00000278829 ENST00000278829	Q9Y5Q0 [Direct mapping] Fatty acid desaturase 3 A0A024R564 [Target identity:100%; Query identity:100%] Fatty acid desaturase 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0006636 [unsaturated fatty acid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	445 aa 51.1 kDa	No	5
FADS3-002 ENSP00000432206 ENST00000525588	E9PS00 [Direct mapping] Fatty acid desaturase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] Show all	417 aa 48.2 kDa	No	5
FADS3-006 ENSP00000436890 ENST00000531956	E9PQC2 [Direct mapping] Fatty acid desaturase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] Show all	199 aa 23.1 kDa	No	4
FADS3-008 ENSP00000435597 ENST00000527379	H0YED5 [Direct mapping] Fatty acid desaturase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] Show all	229 aa 26.6 kDa	No	2
FADS3-009 ENSP00000432012 ENST00000525094	H0YCN1 [Direct mapping] Fatty acid desaturase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] Show all	116 aa 13.6 kDa	No	0
FADS3-012 ENSP00000431533 ENST00000527697	E9PKP8 [Direct mapping] Fatty acid desaturase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	330 aa 38.3 kDa	No	4
FADS3-013 ENSP00000434551 ENST00000534223	E9PPZ4 [Direct mapping] Fatty acid desaturase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] Show all	188 aa 21.9 kDa	No	3

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.