Tissue expression of GPX5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GPX5
Gene description	Glutathione peroxidase 5
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (epididymis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enriched (epididymis)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (epididymis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (epididymis)

GENE INFORMATION
Gene name	GPX5
Synonyms
Description	Glutathione peroxidase 5 (HGNC Symbol)
Entrez gene summary	This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2008]
Chromosome	6
Cytoband	p22.1
Chromosome location (bp)	28525925 - 28534952
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000224586 (version 83.38)
Entrez gene	2880
UniProt	O75715 (UniProt - Evidence at protein level)
neXtProt	NX_O75715
Antibodypedia	GPX5 antibodies

PROTEIN BROWSER

GPX5-001	GPX5-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPX5-001 ENSP00000392398 ENST00000412168	O75715 [Direct mapping] Epididymal secretory glutathione peroxidase V9HWN8 [Target identity:100%; Query identity:100%] Glutathione peroxidase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004602 [glutathione peroxidase activity] GO:0005615 [extracellular space] GO:0006629 [lipid metabolic process] GO:0006979 [response to oxidative stress] GO:0034599 [cellular response to oxidative stress] GO:0055114 [oxidation-reduction process] GO:0097524 [sperm plasma membrane] Show all	221 aa 25.2 kDa	Yes	0
GPX5-005 ENSP00000419935 ENST00000469384	O75715 [Direct mapping] Epididymal secretory glutathione peroxidase Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004602 [glutathione peroxidase activity] GO:0006629 [lipid metabolic process] GO:0006979 [response to oxidative stress] GO:0055114 [oxidation-reduction process] Show all	100 aa 11.4 kDa	Yes	0