Cell atlas - APOC4-APOC2 - The Human Protein Atlas

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APOC4-APOC2

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	APOC4-APOC2
Gene description	APOC4-APOC2 readthrough (NMD candidate)
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (THP-1, Hep G2, HMC-1)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (THP-1, Hep G2, HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	APOC4-APOC2
Synonyms
Description	APOC4-APOC2 readthrough (NMD candidate) (HGNC Symbol)
Entrez gene summary	This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	44942238 - 44949565
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000224916 (version 83.38)
Entrez gene	344
UniProt
neXtProt
Antibodypedia	APOC4-APOC2 antibodies

PROTEIN BROWSER

APOC4-APOC2-001	APOC4-APOC2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOC4-APOC2-001 ENSP00000468139 ENST00000589057	K7ER74 [Direct mapping] Protein APOC4-APOC2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0008047 [enzyme activator activity] GO:0042627 [chylomicron] GO:0043085 [positive regulation of catalytic activity] Show all	178 aa 20 kDa	Yes	1
APOC4-APOC2-201 ENSP00000252490 ENST00000252490	A0A024R0T9 [Direct mapping] Apolipoprotein C-II, isoform CRA_a; Protein APOC4-APOC2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0006869 [lipid transport] GO:0008047 [enzyme activator activity] GO:0042627 [chylomicron] GO:0043085 [positive regulation of catalytic activity] Show all	101 aa 11.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.