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SLC26A6

CANCER ATLAS

Gene description

 Solute carrier family 26 (anion exchanger), member 6

Protein class

 Plasma proteins, Predicted membrane proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048363

GENE INFORMATION

Gene name

 SLC26A6 (HGNC Symbol)

Synonyms

 DKFZp586E1422

Description

 Solute carrier family 26 (anion exchanger), member 6 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 48625723 - 48635493

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000225697 (version 83.38)

Entrez gene

 65010

UniProt

 Q9BXS9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BXS9

Antibodypedia

 SLC26A6 antibodies

PROTEIN BROWSER
SLC26A6-001
SLC26A6-004
SLC26A6-005
SLC26A6-006
SLC26A6-009
SLC26A6-015
SLC26A6-021
SLC26A6-022
SLC26A6-201
SLC26A6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC26A6-001
ENSP00000404684
ENST00000420764
Q9BXS9 [Direct mapping]
Solute carrier family 26 member 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0012506 [vesicle membrane]
GO:0015106 [bicarbonate transmembrane transporter activity]
GO:0015108 [chloride transmembrane transporter activity]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0015301 [anion:anion antiporter activity]
GO:0015499 [formate transmembrane transporter activity]
GO:0015562 [efflux transmembrane transporter activity]
GO:0015659 [formate uptake transmembrane transporter activity]
GO:0015660 [formate efflux transmembrane transporter activity]
GO:0015701 [bicarbonate transport]
GO:0015724 [formate transport]
GO:0015797 [mannitol transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019531 [oxalate transmembrane transporter activity]
GO:0019532 [oxalate transport]
GO:0030165 [PDZ domain binding]
GO:0030321 [transepithelial chloride transport]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031526 [brush border membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0034707 [chloride channel complex]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0042045 [epithelial fluid transport]
GO:0042391 [regulation of membrane potential]
GO:0046724 [oxalic acid secretion]
GO:0048240 [sperm capacitation]
GO:0050892 [intestinal absorption]
GO:0051453 [regulation of intracellular pH]
GO:0051454 [intracellular pH elevation]
GO:0055085 [transmembrane transport]
GO:0070528 [protein kinase C signaling]
GO:0070633 [transepithelial transport]
GO:0071320 [cellular response to cAMP]
GO:0071332 [cellular response to fructose stimulus]
GO:0071346 [cellular response to interferon-gamma]
GO:0097225 [sperm midpiece]
GO:0098656 [anion transmembrane transport]
GO:1902358 [sulfate transmembrane transport]
GO:1902476 [chloride transmembrane transport]
GO:2001150 [positive regulation of dipeptide transmembrane transport]
Show all
 758 aa
82.8 kDa 		No >9
SLC26A6-004
ENSP00000378920
ENST00000395550
Q9BXS9 [Direct mapping]
Solute carrier family 26 member 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0012506 [vesicle membrane]
GO:0015106 [bicarbonate transmembrane transporter activity]
GO:0015108 [chloride transmembrane transporter activity]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0015301 [anion:anion antiporter activity]
GO:0015499 [formate transmembrane transporter activity]
GO:0015562 [efflux transmembrane transporter activity]
GO:0015659 [formate uptake transmembrane transporter activity]
GO:0015660 [formate efflux transmembrane transporter activity]
GO:0015701 [bicarbonate transport]
GO:0015724 [formate transport]
GO:0015797 [mannitol transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019531 [oxalate transmembrane transporter activity]
GO:0019532 [oxalate transport]
GO:0030165 [PDZ domain binding]
GO:0030321 [transepithelial chloride transport]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031526 [brush border membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0034707 [chloride channel complex]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0042045 [epithelial fluid transport]
GO:0042391 [regulation of membrane potential]
GO:0046724 [oxalic acid secretion]
GO:0048240 [sperm capacitation]
GO:0050892 [intestinal absorption]
GO:0051453 [regulation of intracellular pH]
GO:0051454 [intracellular pH elevation]
GO:0055085 [transmembrane transport]
GO:0070528 [protein kinase C signaling]
GO:0070633 [transepithelial transport]
GO:0071320 [cellular response to cAMP]
GO:0071332 [cellular response to fructose stimulus]
GO:0071346 [cellular response to interferon-gamma]
GO:0097225 [sperm midpiece]
GO:0098656 [anion transmembrane transport]
GO:1902358 [sulfate transmembrane transport]
GO:1902476 [chloride transmembrane transport]
GO:2001150 [positive regulation of dipeptide transmembrane transport]
Show all
 759 aa
83 kDa 		No >9
SLC26A6-005
ENSP00000337648
ENST00000337000
G3XAC1 [Direct mapping]
Solute carrier family 26 member 6; Solute carrier family 26, member 6, isoform CRA_i
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:1902358 [sulfate transmembrane transport]
Show all
 651 aa
71.5 kDa 		No 9
SLC26A6-006
ENSP00000373239
ENST00000383733
Q9BXS9 [Direct mapping]
Solute carrier family 26 member 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0012506 [vesicle membrane]
GO:0015106 [bicarbonate transmembrane transporter activity]
GO:0015108 [chloride transmembrane transporter activity]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0015301 [anion:anion antiporter activity]
GO:0015499 [formate transmembrane transporter activity]
GO:0015562 [efflux transmembrane transporter activity]
GO:0015659 [formate uptake transmembrane transporter activity]
GO:0015660 [formate efflux transmembrane transporter activity]
GO:0015701 [bicarbonate transport]
GO:0015724 [formate transport]
GO:0015797 [mannitol transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019531 [oxalate transmembrane transporter activity]
GO:0019532 [oxalate transport]
GO:0030165 [PDZ domain binding]
GO:0030321 [transepithelial chloride transport]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031526 [brush border membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0034707 [chloride channel complex]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0042045 [epithelial fluid transport]
GO:0042391 [regulation of membrane potential]
GO:0046724 [oxalic acid secretion]
GO:0048240 [sperm capacitation]
GO:0050892 [intestinal absorption]
GO:0051453 [regulation of intracellular pH]
GO:0051454 [intracellular pH elevation]
GO:0055085 [transmembrane transport]
GO:0070528 [protein kinase C signaling]
GO:0070633 [transepithelial transport]
GO:0071320 [cellular response to cAMP]
GO:0071332 [cellular response to fructose stimulus]
GO:0071346 [cellular response to interferon-gamma]
GO:0097225 [sperm midpiece]
GO:0098656 [anion transmembrane transport]
GO:1902358 [sulfate transmembrane transport]
GO:1902476 [chloride transmembrane transport]
GO:2001150 [positive regulation of dipeptide transmembrane transport]
Show all
 740 aa
80.8 kDa 		No >9
SLC26A6-009
ENSP00000401066
ENST00000455886
Q9BXS9 [Direct mapping]
Solute carrier family 26 member 6
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0012506 [vesicle membrane]
GO:0015106 [bicarbonate transmembrane transporter activity]
GO:0015108 [chloride transmembrane transporter activity]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0015301 [anion:anion antiporter activity]
GO:0015499 [formate transmembrane transporter activity]
GO:0015562 [efflux transmembrane transporter activity]
GO:0015659 [formate uptake transmembrane transporter activity]
GO:0015660 [formate efflux transmembrane transporter activity]
GO:0015701 [bicarbonate transport]
GO:0015724 [formate transport]
GO:0015797 [mannitol transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019531 [oxalate transmembrane transporter activity]
GO:0019532 [oxalate transport]
GO:0030165 [PDZ domain binding]
GO:0030321 [transepithelial chloride transport]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031526 [brush border membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0034707 [chloride channel complex]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0042045 [epithelial fluid transport]
GO:0042391 [regulation of membrane potential]
GO:0046724 [oxalic acid secretion]
GO:0048240 [sperm capacitation]
GO:0050892 [intestinal absorption]
GO:0051453 [regulation of intracellular pH]
GO:0051454 [intracellular pH elevation]
GO:0055085 [transmembrane transport]
GO:0070528 [protein kinase C signaling]
GO:0070633 [transepithelial transport]
GO:0071320 [cellular response to cAMP]
GO:0071332 [cellular response to fructose stimulus]
GO:0071346 [cellular response to interferon-gamma]
GO:0097225 [sperm midpiece]
GO:0098656 [anion transmembrane transport]
GO:1902358 [sulfate transmembrane transport]
GO:1902476 [chloride transmembrane transport]
GO:2001150 [positive regulation of dipeptide transmembrane transport]
Show all
 723 aa
79.2 kDa 		No >9
SLC26A6-015
ENSP00000389922
ENST00000421649
H7BZJ6 [Direct mapping]
Solute carrier family 26 member 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0016021 [integral component of membrane]
GO:1902358 [sulfate transmembrane transport]
Show all
 303 aa
32.3 kDa 		No 9
SLC26A6-021
ENSP00000401813
ENST00000431739
C9JKR6 [Direct mapping]
Solute carrier family 26 member 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0016021 [integral component of membrane]
GO:1902358 [sulfate transmembrane transport]
Show all
 180 aa
20.2 kDa 		No 2
SLC26A6-022
ENSP00000405872
ENST00000426599
C9J6Y3 [Direct mapping]
Solute carrier family 26 member 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0016021 [integral component of membrane]
GO:1902358 [sulfate transmembrane transport]
Show all
 169 aa
18.8 kDa 		No 3
SLC26A6-201
ENSP00000351597
ENST00000358747
A0A0C4DFT5 [Direct mapping]
Solute carrier family 26 member 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:1902358 [sulfate transmembrane transport]
Show all
 738 aa
80.9 kDa 		No >9
SLC26A6-202
ENSP00000483669
ENST00000614797
Q86YZ4 [Direct mapping]
Solute carrier family 26 member 6; Solute carrier family 26, member 6
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:1902358 [sulfate transmembrane transport]
Show all
 753 aa
82.3 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.