Cell atlas - SCAMP4 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SCAMP4
Gene description	Secretory carrier membrane protein 4
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus & vesicles. In addition localized to the plasma membrane & lipid droplets.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved), Vesicles (approved)
Additional location	In addition localized to the Lipid droplets (approved), Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA043284
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus & vesicles. In addition localized to the plasma membrane & lipid droplets.

Main location

Golgi apparatus (approved), Vesicles (approved)

Additional location

Lipid droplets (approved), Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA043284	A-431	Golgi apparatus
		Vesicles
		Plasma membrane
HPA043284	U-2 OS	Lipid droplets
HPA043284	U-251 MG	Golgi apparatus
HPA043284	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	SCAMP4 (HGNC Symbol)
Synonyms	FLJ33847
Description	Secretory carrier membrane protein 4 (HGNC Symbol)
Entrez gene summary	Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by OMIM, Feb 2011]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	1905214 - 1926013
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000227500 (version 83.38)
Entrez gene	113178
UniProt	Q969E2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q969E2
Antibodypedia	SCAMP4 antibodies

PROTEIN BROWSER

SCAMP4-001	SCAMP4-003	SCAMP4-008	SCAMP4-009	SCAMP4-011	SCAMP4-012	SCAMP4-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCAMP4-001 ENSP00000316007 ENST00000316097	Q969E2 [Direct mapping] Secretory carrier-associated membrane protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0030133 [transport vesicle] Show all	229 aa 25.7 kDa	No	4
SCAMP4-003 ENSP00000386865 ENST00000409472	Q969E2 [Direct mapping] Secretory carrier-associated membrane protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	195 aa 22 kDa	No	3
SCAMP4-008 ENSP00000388185 ENST00000411971	C9JWM2 [Direct mapping] Secretory carrier-associated membrane protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	123 aa 14.3 kDa	No	3
SCAMP4-009 ENSP00000465199 ENST00000590266	K7EJJ4 [Direct mapping] Secretory carrier-associated membrane protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	57 aa 6.8 kDa	No	1
SCAMP4-011 ENSP00000479672 ENST00000414057	A0A087WVT5 [Direct mapping] Secretory carrier-associated membrane protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	140 aa 15.3 kDa	No	3
SCAMP4-012 ENSP00000479083 ENST00000621748	Q969E2 [Direct mapping] Secretory carrier-associated membrane protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	229 aa 25.7 kDa	No	4
SCAMP4-013 ENSP00000478264 ENST00000588907	A0A087WU01 [Direct mapping] Secretory carrier-associated membrane protein 4 Show all	TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		22 aa 2.4 kDa	No	0