Cell atlas - POLR2J2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

POLR2J2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	POLR2J2
Gene description	Polymerase (RNA) II (DNA directed) polypeptide J2
Protein class	Predicted intracellular proteins RNA polymerase related proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (MOLT-4, U-2 OS)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA046970
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (MOLT-4, U-2 OS) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046970	A-431	Nucleoplasm

GENE INFORMATION
Gene name	POLR2J2 (HGNC Symbol)
Synonyms	RPB11b1
Description	Polymerase (RNA) II (DNA directed) polypeptide J2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	102665368 - 102671629
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000228049 (version 83.38)
Entrez gene	246721
UniProt	Q9GZM3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9GZM3
Antibodypedia	POLR2J2 antibodies

PROTEIN BROWSER

POLR2J2-002	POLR2J2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POLR2J2-002 ENSP00000351218 ENST00000358438	A6NFM0 [Direct mapping] DNA-directed RNA polymerase II subunit RPB11-b1 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001055 [RNA polymerase II activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0006351 [transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] Show all	158 aa 17.2 kDa	No	0
POLR2J2-003 ENSP00000330898 ENST00000333432	Q9GZM3 [Direct mapping] DNA-directed RNA polymerase II subunit RPB11-b1 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001055 [RNA polymerase II activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0006351 [transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] Show all	115 aa 13.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.