We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
APOC2
  • premium

    TISSUE

  • CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Apolipoprotein C-II

Protein class

Candidate cardiovascular disease genes, Disease related genes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA055877

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong cytoplasmic immunoreactivity was observed in hepatocellular carcinomas and occasional malignant melanomas and carcinoids. Remaining cancer tissues were negative.

GENE INFORMATION

Gene name

APOC2

Synonyms

Description

Apolipoprotein C-II (HGNC Symbol)

Entrez gene summary

Chromosome

19

Cytoband

q13.32

Chromosome location (bp)

44946035 - 44949565

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000234906 (version 83.38)

Entrez gene

UniProt

P02655 (UniProt - Evidence at protein level)

neXtProt

NX_P02655

Antibodypedia

APOC2 antibodies

PROTEIN BROWSER

APOC2-001
APOC2-002
APOC2-003
APOC2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APOC2-001
ENSP00000466775
ENST00000590360
P02655 [Direct mapping]
Apolipoprotein C-II Proapolipoprotein C-II
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001523 [retinoid metabolic process]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0006629 [lipid metabolic process]
GO:0006869 [lipid transport]
GO:0007603 [phototransduction, visible light]
GO:0008047 [enzyme activator activity]
GO:0008289 [lipid binding]
GO:0010518 [positive regulation of phospholipase activity]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0010902 [positive regulation of very-low-density lipoprotein particle remodeling]
GO:0010916 [negative regulation of very-low-density lipoprotein particle clearance]
GO:0016004 [phospholipase activator activity]
GO:0016042 [lipid catabolic process]
GO:0032375 [negative regulation of cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034362 [low-density lipoprotein particle]
GO:0034363 [intermediate-density lipoprotein particle]
GO:0034366 [spherical high-density lipoprotein particle]
GO:0034370 [triglyceride-rich lipoprotein particle remodeling]
GO:0034371 [chylomicron remodeling]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034382 [chylomicron remnant clearance]
GO:0034384 [high-density lipoprotein particle clearance]
GO:0042157 [lipoprotein metabolic process]
GO:0042627 [chylomicron]
GO:0042632 [cholesterol homeostasis]
GO:0042803 [protein homodimerization activity]
GO:0043086 [negative regulation of catalytic activity]
GO:0043274 [phospholipase binding]
GO:0043691 [reverse cholesterol transport]
GO:0044281 [small molecule metabolic process]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0045833 [negative regulation of lipid metabolic process]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0055102 [lipase inhibitor activity]
GO:0060230 [lipoprotein lipase activator activity]
GO:0060697 [positive regulation of phospholipid catabolic process]
GO:0070062 [extracellular exosome]
GO:0070328 [triglyceride homeostasis]
Show all
101 aa
11.3 kDa
Yes 0
APOC2-002
ENSP00000465001
ENST00000585786
Q6P163 [Direct mapping]
APOC2 protein; Apolipoprotein C-II
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006629 [lipid metabolic process]
GO:0006869 [lipid transport]
GO:0008047 [enzyme activator activity]
GO:0042627 [chylomicron]
GO:0043085 [positive regulation of catalytic activity]
Show all
72 aa
8.1 kDa
Yes 0
APOC2-003
ENSP00000477261
ENST00000592257
V9GZ01 [Direct mapping]
Apolipoprotein C-II
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
47 aa
5.1 kDa
Yes 0
APOC2-004
ENSP00000476835
ENST00000591597
V9GYJ8 [Direct mapping]
Apolipoprotein C-II
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006629 [lipid metabolic process]
GO:0006869 [lipid transport]
GO:0008047 [enzyme activator activity]
GO:0042627 [chylomicron]
GO:0043085 [positive regulation of catalytic activity]
Show all
87 aa
9.6 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.