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Weak to moderate cytoplasmic immunoreactivity was observed in melanomas and thyroid cancers along with several endometrial, colorectal, ovarian, urothelial, testicular and lung cancers. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
RNF103 (HGNC Symbol)
Synonyms
hkf-1, KF1, ZFP103
Description
Ring finger protein 103 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011]
