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DEFA3

GENERAL INFORMATION

Gene name

 DEFA3

Gene description

 Defensin, alpha 3, neutrophil-specific

Protein class

 Cancer-related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (bone marrow)
GTEx:Group enriched (spleen, lung)
FANTOM5:Tissue enhanced (heart muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in immune cells in hematopoietic and lymphoid tissue.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 1 antibody.
HPA052517
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)

GENE INFORMATION

Gene name

 DEFA3 (HGNC Symbol)

Synonyms

 DEF3, HNP-3

Description

 Defensin, alpha 3, neutrophil-specific (HGNC Symbol)

Entrez gene summary

 Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation. [provided by RefSeq, Oct 2014]

Chromosome

 8

Cytoband

 p23.1

Chromosome location (bp)

 6996837 - 7018301

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000239839 (version 83.38)

Entrez gene

 1668

UniProt

 P59666 (UniProt - Evidence at protein level)

neXtProt

 NX_P59666

Antibodypedia

 DEFA3 antibodies

PROTEIN BROWSER
DEFA3-001
DEFA3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DEFA3-001
ENSP00000328359
ENST00000327857
P59666 [Direct mapping]
Neutrophil defensin 3 HP 3-56 Neutrophil defensin 2
Q6EZE9 [Target identity:100%; Query identity:100%]
Defensin, alpha 3, neutrophil-specific
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002227 [innate immune response in mucosa]
GO:0003674 [molecular_function]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0006952 [defense response]
GO:0019731 [antibacterial humoral response]
GO:0030520 [intracellular estrogen receptor signaling pathway]
GO:0031640 [killing of cells of other organism]
GO:0035578 [azurophil granule lumen]
GO:0045087 [innate immune response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0050832 [defense response to fungus]
GO:0051607 [defense response to virus]
GO:0070062 [extracellular exosome]
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 94 aa
10.2 kDa 		Yes 0
DEFA3-201
ENSP00000484218
ENST00000616150
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006952 [defense response]
Show all
 94 aa
10.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.