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Most cancer cells showed moderate to strong cytoplasmic immunoreactivity with a granular pattern. Several cases of squamous cell carcinomas, gliomas, urothelial and pancreatic cancers were weakly stained or negative.
GENE INFORMATION
Gene name
TNFRSF13B (HGNC Symbol)
Synonyms
CD267, IGAD2, TACI
Description
Tumor necrosis factor receptor superfamily, member 13B (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]