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This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001516 [prostaglandin biosynthetic process] GO:0001934 [positive regulation of protein phosphorylation] GO:0002906 [negative regulation of mature B cell apoptotic process] GO:0004167 [dopachrome isomerase activity] GO:0005102 [receptor binding] GO:0005125 [cytokine activity] GO:0005126 [cytokine receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006954 [inflammatory response] GO:0007166 [cell surface receptor signaling pathway] GO:0007569 [cell aging] GO:0008283 [cell proliferation] GO:0009986 [cell surface] GO:0010629 [negative regulation of gene expression] GO:0010739 [positive regulation of protein kinase A signaling] GO:0019752 [carboxylic acid metabolic process] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0030890 [positive regulation of B cell proliferation] GO:0031666 [positive regulation of lipopolysaccharide-mediated signaling pathway] GO:0031982 [vesicle] GO:0032269 [negative regulation of cellular protein metabolic process] GO:0033033 [negative regulation of myeloid cell apoptotic process] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0042056 [chemoattractant activity] GO:0042127 [regulation of cell proliferation] GO:0042327 [positive regulation of phosphorylation] GO:0043030 [regulation of macrophage activation] GO:0043066 [negative regulation of apoptotic process] GO:0043209 [myelin sheath] GO:0043406 [positive regulation of MAP kinase activity] GO:0043518 [negative regulation of DNA damage response, signal transduction by p53 class mediator] GO:0045087 [innate immune response] GO:0048146 [positive regulation of fibroblast proliferation] GO:0050178 [phenylpyruvate tautomerase activity] GO:0050715 [positive regulation of cytokine secretion] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918 [positive chemotaxis] GO:0061078 [positive regulation of prostaglandin secretion involved in immune response] GO:0061081 [positive regulation of myeloid leukocyte cytokine production involved in immune response] GO:0070062 [extracellular exosome] GO:0070207 [protein homotrimerization] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071157 [negative regulation of cell cycle arrest] GO:0090238 [positive regulation of arachidonic acid secretion] GO:0090344 [negative regulation of cell aging] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:2000343 [positive regulation of chemokine (C-X-C motif) ligand 2 production]