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Group enriched (tonsil, lymph node, spleen, urinary bladder)
GTEx:
Group enriched (spleen, small intestine)
FANTOM5:
Group enriched (appendix, tonsil, lymph node, spleen)
Protein evidence
Evidence at protein level
Protein expression
Cytoplasmic expression in a subset of lymphoid cells and secreted positivity in goblet cells.
DATA RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
RNA tissue category: Group enriched (spleen, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (appendix, tonsil, lymph node, spleen)
GENE INFORMATION
Gene name
HLA-DOB
Synonyms
Description
Major histocompatibility complex, class II, DO beta (HGNC Symbol)
Entrez gene summary
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
P13765 [Direct mapping] HLA class II histocompatibility antigen, DO beta chain Q5QNS2 [Target identity:100%; Query identity:100%] MHC class II antigen; Major histocompatibility complex, class II, DO beta, isoform CRA_a
GO:0002587 [negative regulation of antigen processing and presentation of peptide antigen via MHC class II] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0023026 [MHC class II protein complex binding] GO:0032395 [MHC class II receptor activity] GO:0042613 [MHC class II protein complex]
H0Y4X4 [Direct mapping] HLA class II histocompatibility antigen, DO beta chain
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Predicted intracellular proteins
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GO:0002504 [antigen processing and presentation of peptide or polysaccharide antigen via MHC class II] GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0042613 [MHC class II protein complex]
