Expression of ATP5J2 in cancer - Summary

CANCER ATLAS

Gene description

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA070412

GENE INFORMATION
Gene name	ATP5J2 (HGNC Symbol)
Synonyms	ATP5JL, F1Fo-ATPase
Description	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 (HGNC Symbol)
Entrez gene summary	Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The catalytic portion of mitochondrial ATP synthase consists of five different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has multiple pseudogenes. Naturally occurring read-through transcription also exists between this gene and the downstream pentatricopeptide repeat domain 1 (PTCD1) gene. [provided by RefSeq, Nov 2010]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	99448475 - 99466331
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000241468 (version 83.38)
Entrez gene	9551
UniProt	P56134 (UniProt - Evidence at protein level)
neXtProt	NX_P56134
Antibodypedia	ATP5J2 antibodies

PROTEIN BROWSER

ATP5J2-001	ATP5J2-006	ATP5J2-009	ATP5J2-012	ATP5J2-013	ATP5J2-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP5J2-001 ENSP00000292475 ENST00000292475	P56134 [Direct mapping] ATP synthase subunit f, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000276 [mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0022857 [transmembrane transporter activity] GO:0022904 [respiratory electron transport chain] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046034 [ATP metabolic process] GO:0070062 [extracellular exosome] Show all	94 aa 10.9 kDa	No	1
ATP5J2-006 ENSP00000407540 ENST00000449683	C9JU26 [Direct mapping] ATP synthase subunit f, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	98 aa 11.4 kDa	No	1
ATP5J2-009 ENSP00000352890 ENST00000359832	P56134 [Direct mapping] ATP synthase subunit f, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005743 [mitochondrial inner membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0022857 [transmembrane transporter activity] GO:0022904 [respiratory electron transport chain] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	55 aa 6.3 kDa	No	0
ATP5J2-012 ENSP00000418197 ENST00000488775	P56134 [Direct mapping] ATP synthase subunit f, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005743 [mitochondrial inner membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0022857 [transmembrane transporter activity] GO:0022904 [respiratory electron transport chain] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	49 aa 5.7 kDa	No	0
ATP5J2-013 ENSP00000377740 ENST00000394186	P56134 [Direct mapping] ATP synthase subunit f, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005743 [mitochondrial inner membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0015992 [proton transport] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0022857 [transmembrane transporter activity] GO:0022904 [respiratory electron transport chain] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	88 aa 10.4 kDa	No	1
ATP5J2-015 ENSP00000430398 ENST00000523680	E5RKA0 [Direct mapping] ATP synthase subunit f, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		19 aa 2.2 kDa	No	0