Expression of SSX2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Synovial sarcoma, X breakpoint 2

Protein class

Cancer-related genes, Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA045683	CAB046020

GENE INFORMATION
Gene name	SSX2 (HGNC Symbol)
Synonyms	CT5.2a, HD21, HOM-MEL-40, MGC119055, MGC15364, MGC3884, SSX
Description	Synovial sarcoma, X breakpoint 2 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X. [provided by RefSeq, Jul 2013]
Chromosome	X
Cytoband	p11.22
Chromosome location (bp)	52644567 - 52707189
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000241476 (version 83.38)
Entrez gene	6757
UniProt	Q16385 (UniProt - Evidence at protein level)
neXtProt	NX_Q16385
Antibodypedia	SSX2 antibodies

PROTEIN BROWSER

SSX2-001	SSX2-002	SSX2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SSX2-001 ENSP00000338796 ENST00000336777	Q16385 [Direct mapping] Protein SSX2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0003676 [nucleic acid binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	223 aa 25.2 kDa	No	0
SSX2-002 ENSP00000338561 ENST00000337502	Q16385 [Direct mapping] Protein SSX2 Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0003676 [nucleic acid binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	188 aa 21.6 kDa	No	0
SSX2-201 ENSP00000479759 ENST00000610779	A0A087WVX7 [Direct mapping] Protein SSX2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	188 aa 21.5 kDa	No	0