Tissue expression of ARHGAP8 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ARHGAP8
Gene description	Rho GTPase activating protein 8
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Tissue enhanced (salivary gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (salivary gland)

GENE INFORMATION
Gene name	ARHGAP8 (HGNC Symbol)
Synonyms	BPGAP1, FLJ20185
Description	Rho GTPase activating protein 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq, Nov 2010]
Chromosome	22
Cytoband	q13.31
Chromosome location (bp)	44752558 - 44862788
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000241484 (version 83.38)
Entrez gene	23779
UniProt	P85298 (UniProt - Evidence at protein level)
neXtProt	NX_P85298
Antibodypedia	ARHGAP8 antibodies

PROTEIN BROWSER

ARHGAP8-001	ARHGAP8-003	ARHGAP8-004	ARHGAP8-010	ARHGAP8-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGAP8-001 ENSP00000374424 ENST00000389774	P85298 [Direct mapping] Rho GTPase-activating protein 8 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	464 aa 53.5 kDa	No	0
ARHGAP8-003 ENSP00000337287 ENST00000336963	P85298 [Direct mapping] Rho GTPase-activating protein 8 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	305 aa 35.6 kDa	No	0
ARHGAP8-004 ENSP00000348407 ENST00000356099	P85298 [Direct mapping] Rho GTPase-activating protein 8 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	433 aa 49.8 kDa	No	0
ARHGAP8-010 ENSP00000402775 ENST00000412433	B1AHC2 [Direct mapping] Rho GTPase-activating protein 8 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] Show all	115 aa 13.5 kDa	No	0
ARHGAP8-012 ENSP00000379425 ENST00000396119	B1AHF8 [Direct mapping] Rho GTPase-activating protein 8 Show all	Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] Show all	130 aa 15.3 kDa	No	0