Expression of ARPC1A in cancer - Summary

CANCER ATLAS

Gene description

Actin related protein 2/3 complex, subunit 1A, 41kDa

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA004334

GENE INFORMATION
Gene name	ARPC1A (HGNC Symbol)
Synonyms	Arc40, SOP2Hs, SOP2L
Description	Actin related protein 2/3 complex, subunit 1A, 41kDa (HGNC Symbol)
Entrez gene summary	This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	99325898 - 99388164
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000241685 (version 83.38)
Entrez gene	10552
UniProt	Q92747 (UniProt - Evidence at protein level)
neXtProt	NX_Q92747
Antibodypedia	ARPC1A antibodies

PROTEIN BROWSER

ARPC1A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARPC1A-001 ENSP00000262942 ENST00000262942	Q92747 [Direct mapping] Actin-related protein 2/3 complex subunit 1A V9HVZ6 [Target identity:100%; Query identity:100%] Epididymis luminal protein 68 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005885 [Arp2/3 protein complex] GO:0007264 [small GTPase mediated signal transduction] GO:0007411 [axon guidance] GO:0015629 [actin cytoskeleton] GO:0030036 [actin cytoskeleton organization] GO:0030833 [regulation of actin filament polymerization] GO:0034314 [Arp2/3 complex-mediated actin nucleation] GO:0036195 [muscle cell projection membrane] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0045087 [innate immune response] GO:0048013 [ephrin receptor signaling pathway] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	370 aa 41.6 kDa	No	0