Expression of PISD in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Phosphatidylserine decarboxylase

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA031090	HPA031091

GENE INFORMATION
Gene name	PISD (HGNC Symbol)
Synonyms	dJ858B16.2, PSDC
Description	Phosphatidylserine decarboxylase (HGNC Symbol)
Entrez gene summary	Phosphatidylserine decarboxylases (PSDs; EC 4.1.1.65) catalyze the formation of phosphatidylethanolamine (PE) by decarboxylation of phosphatidylserine (PS). Type I PSDs, such as PISD, are targeted to the inner mitochondrial membrane by an N-terminal targeting sequence. PISD also contains a conserved LGST motif that functions as an autocatalytic cleavage site where the proenzyme is split into mature alpha and beta subunits (Schuiki and Daum, 2009 [PubMed 19165886]).[supplied by OMIM, Jul 2010]
Chromosome	22
Cytoband	q12.2
Chromosome location (bp)	31618491 - 31662432
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000241878 (version 83.38)
Entrez gene	23761
UniProt	Q9UG56 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UG56
Antibodypedia	PISD antibodies

PROTEIN BROWSER

PISD-001	PISD-004	PISD-006	PISD-007	PISD-009	PISD-010	PISD-012	PISD-014	PISD-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PISD-001 ENSP00000391739 ENST00000439502	Q9UG56 [Direct mapping] Phosphatidylserine decarboxylase proenzyme Phosphatidylserine decarboxylase alpha chain Phosphatidylserine decarboxylase beta chain Show all	Enzymes ENZYME proteins Lyases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004609 [phosphatidylserine decarboxylase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0008654 [phospholipid biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	409 aa 46.7 kDa	No	0
PISD-004 ENSP00000414395 ENST00000435900	H0Y7P7 [Direct mapping] Phosphatidylserine decarboxylase proenzyme Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004609 [phosphatidylserine decarboxylase activity] GO:0008654 [phospholipid biosynthetic process] Show all	362 aa 41.3 kDa	No	0
PISD-006 ENSP00000380637 ENST00000397500	B1AKM6 [Direct mapping] Phosphatidylserine decarboxylase proenzyme Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004609 [phosphatidylserine decarboxylase activity] GO:0008654 [phospholipid biosynthetic process] Show all	262 aa 30.3 kDa	No	1
PISD-007 ENSP00000371586 ENST00000382151	Q9UG56 [Direct mapping] Phosphatidylserine decarboxylase proenzyme Phosphatidylserine decarboxylase alpha chain Phosphatidylserine decarboxylase beta chain A0A024R1K5 [Target identity:100%; Query identity:100%] Phosphatidylserine decarboxylase, isoform CRA_a Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004609 [phosphatidylserine decarboxylase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0008654 [phospholipid biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	375 aa 43 kDa	No	1
PISD-009 ENSP00000396002 ENST00000429683	B1AKN0 [Direct mapping] Phosphatidylserine decarboxylase proenzyme Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		73 aa 8.5 kDa	No	1
PISD-010 ENSP00000401606 ENST00000431201	B1AKN0 [Direct mapping] Phosphatidylserine decarboxylase proenzyme Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		73 aa 8.5 kDa	No	1
PISD-012 ENSP00000412169 ENST00000422020	B1AKM8 [Direct mapping] Phosphatidylserine decarboxylase proenzyme Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004609 [phosphatidylserine decarboxylase activity] GO:0008654 [phospholipid biosynthetic process] Show all	228 aa 26.3 kDa	No	0
PISD-014 ENSP00000399818 ENST00000442379	B1AKM9 [Direct mapping] Phosphatidylserine decarboxylase proenzyme Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		81 aa 9.4 kDa	No	1
PISD-201 ENSP00000266095 ENST00000266095	Q9UG56 [Direct mapping] Phosphatidylserine decarboxylase proenzyme Phosphatidylserine decarboxylase alpha chain Phosphatidylserine decarboxylase beta chain A0A024R1K5 [Target identity:100%; Query identity:100%] Phosphatidylserine decarboxylase, isoform CRA_a Show all	Enzymes ENZYME proteins Lyases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004609 [phosphatidylserine decarboxylase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0006644 [phospholipid metabolic process] GO:0006646 [phosphatidylethanolamine biosynthetic process] GO:0008654 [phospholipid biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	375 aa 43 kDa	No	1