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BGLAP

GENERAL INFORMATION

Gene name

 BGLAP

Gene description

 Bone gamma-carboxyglutamate (gla) protein

Protein class

 FDA approved drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (brain, colon, appendix)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, colon, appendix)

GENE INFORMATION

Gene name

 BGLAP (HGNC Symbol)

Synonyms

 OCN

Description

 Bone gamma-carboxyglutamate (gla) protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]

Chromosome

 1

Cytoband

 q22

Chromosome location (bp)

 156241962 - 156243321

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000242252 (version 83.38)

Entrez gene

 632

UniProt

 P02818 (UniProt - Evidence at protein level)

neXtProt

 NX_P02818

Antibodypedia

 BGLAP antibodies

PROTEIN BROWSER
BGLAP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BGLAP-001
ENSP00000357255
ENST00000368272
P02818 [Direct mapping]
Osteocalcin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0001649 [osteoblast differentiation]
GO:0002076 [osteoblast development]
GO:0005198 [structural molecule activity]
GO:0005509 [calcium ion binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005791 [rough endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0007155 [cell adhesion]
GO:0007568 [aging]
GO:0007569 [cell aging]
GO:0008147 [structural constituent of bone]
GO:0009612 [response to mechanical stimulus]
GO:0009629 [response to gravity]
GO:0010035 [response to inorganic substance]
GO:0010043 [response to zinc ion]
GO:0014070 [response to organic cyclic compound]
GO:0014823 [response to activity]
GO:0030282 [bone mineralization]
GO:0030425 [dendrite]
GO:0030500 [regulation of bone mineralization]
GO:0031667 [response to nutrient levels]
GO:0031988 [membrane-bounded vesicle]
GO:0032571 [response to vitamin K]
GO:0033280 [response to vitamin D]
GO:0033574 [response to testosterone]
GO:0033594 [response to hydroxyisoflavone]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0042995 [cell projection]
GO:0043204 [perikaryon]
GO:0043627 [response to estrogen]
GO:0045124 [regulation of bone resorption]
GO:0045471 [response to ethanol]
GO:0045670 [regulation of osteoclast differentiation]
GO:0046848 [hydroxyapatite binding]
GO:0051384 [response to glucocorticoid]
GO:0060348 [bone development]
GO:0071305 [cellular response to vitamin D]
GO:0071363 [cellular response to growth factor stimulus]
Show all
 100 aa
11 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.