Expression of STRC in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Stereocilin

Protein class

Disease related genes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA015731

GENE INFORMATION
Gene name	STRC (HGNC Symbol)
Synonyms	DFNB16
Description	Stereocilin (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is associated with the hair bundle of the sensory hair cells in the inner ear. The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in this gene cause autosomal recessive non-syndromic deafness. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q15.3
Chromosome location (bp)	43599398 - 43618800
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000242866 (version 83.38)
Entrez gene	161497
UniProt	Q7RTU9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q7RTU9
Antibodypedia	STRC antibodies

PROTEIN BROWSER

STRC-001	STRC-005	STRC-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STRC-001 ENSP00000401513 ENST00000450892	Q7RTU9 [Direct mapping] Stereocilin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0007160 [cell-matrix adhesion] GO:0007605 [sensory perception of sound] GO:0009986 [cell surface] GO:0032420 [stereocilium] GO:0032426 [stereocilium bundle tip] GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound] GO:0060088 [auditory receptor cell stereocilium organization] GO:0060091 [kinocilium] Show all	1775 aa 193 kDa	Yes	0
STRC-005 ENSP00000407303 ENST00000432436	H7C2Q6 [Direct mapping] Stereocilin Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all		663 aa 70.9 kDa	No	0
STRC-201 ENSP00000440413 ENST00000541030	F5GXA4 [Direct mapping] Stereocilin Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all		1002 aa 110.7 kDa	No	0