Cell atlas - MICAL3 - The Human Protein Atlas

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MICAL3

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	MICAL3
Gene description	Microtubule associated monooxygenase, calponin and LIM domain containing 3
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Plasma membrane (uncertain), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA003421 , HPA034882
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.

Main location

Nucleoplasm (validated)

Additional location

Plasma membrane (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA003421	SK-MEL-30	Nucleoplasm
	HPA003421	SK-MEL-30	Plasma membrane
	HPA003421	U-2 OS	Nucleoplasm
	HPA003421	U-2 OS	Plasma membrane
	HPA003421	U-251 MG	Nucleoplasm
	HPA003421	U-251 MG	Plasma membrane
	HPA034882	A-431	Nucleoplasm
	HPA034882	A-431	Cytosol
	HPA034882	U-2 OS	Nucleoplasm
	HPA034882	U-2 OS	Cytosol
	HPA034882	U-251 MG	Nucleoplasm
	HPA034882	U-251 MG	Cytosol

GENE INFORMATION
Gene name	MICAL3 (HGNC Symbol)
Synonyms	KIAA0819
Description	Microtubule associated monooxygenase, calponin and LIM domain containing 3 (HGNC Symbol)
Entrez gene summary
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	17787649 - 18024559
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000243156 (version 83.38)
Entrez gene	57553
UniProt	Q7RTP6 (UniProt - Evidence at protein level)
neXtProt	NX_Q7RTP6
Antibodypedia	MICAL3 antibodies

PROTEIN BROWSER

MICAL3-001	MICAL3-002	MICAL3-003	MICAL3-004	MICAL3-006	MICAL3-010	MICAL3-011	MICAL3-012	MICAL3-015	MICAL3-017	MICAL3-018	MICAL3-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MICAL3-001 ENSP00000372574 ENST00000383094	Q7RTP6 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006887 [exocytosis] GO:0007010 [cytoskeleton organization] GO:0008270 [zinc ion binding] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0030042 [actin filament depolymerization] GO:0043914 [NADPH:sulfur oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding] Show all	948 aa 106.8 kDa	No	0
MICAL3-002 ENSP00000391827 ENST00000414725	Q7RTP6 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006887 [exocytosis] GO:0007010 [cytoskeleton organization] GO:0008270 [zinc ion binding] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0030042 [actin filament depolymerization] GO:0043914 [NADPH:sulfur oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding] Show all	976 aa 109.9 kDa	No	0
MICAL3-003 ENSP00000383406 ENST00000400561	Q7RTP6 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006887 [exocytosis] GO:0007010 [cytoskeleton organization] GO:0008270 [zinc ion binding] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0030042 [actin filament depolymerization] GO:0043914 [NADPH:sulfur oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding] Show all	966 aa 109 kDa	No	0
MICAL3-004 ENSP00000462531 ENST00000461307	J3KSK6 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	496 aa 55.3 kDa	No	1
MICAL3-006 ENSP00000406193 ENST00000424046	C9J922 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL3 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0071949 [FAD binding] Show all	125 aa 14.3 kDa	No	0
MICAL3-010 ENSP00000416015 ENST00000441493	Q7RTP6 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL3 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006887 [exocytosis] GO:0007010 [cytoskeleton organization] GO:0008270 [zinc ion binding] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0030042 [actin filament depolymerization] GO:0043914 [NADPH:sulfur oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding] Show all	2002 aa 224.3 kDa	No	0
MICAL3-011 ENSP00000464007 ENST00000498573	J3QR21 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL3 Show all	Predicted intracellular proteins Show all		198 aa 21.7 kDa	No	0
MICAL3-012 ENSP00000462033 ENST00000585038	Q7RTP6 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0006887 [exocytosis] GO:0007010 [cytoskeleton organization] GO:0008270 [zinc ion binding] GO:0010735 [positive regulation of transcription via serum response element binding] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0030042 [actin filament depolymerization] GO:0043914 [NADPH:sulfur oxidoreductase activity] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding] Show all	1073 aa 121.2 kDa	No	2
MICAL3-015 ENSP00000463882 ENST00000577821	J3QQT0 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL3 Show all	Predicted intracellular proteins Show all		270 aa 31.1 kDa	No	0
MICAL3-017 ENSP00000463453 ENST00000578984	J3QLA3 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL3 Show all	Predicted intracellular proteins Show all		190 aa 20.9 kDa	No	0
MICAL3-018 ENSP00000462905 ENST00000584751	J3KTB6 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL3 Show all	Predicted intracellular proteins Show all		139 aa 15.5 kDa	No	0
MICAL3-019 ENSP00000462107 ENST00000579997	J3KRP8 [Direct mapping] Protein-methionine sulfoxide oxidase MICAL3 Show all	Predicted intracellular proteins Show all		173 aa 19.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.