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Malignant cells generally showed weak to moderate cytoplasmic and nuclear positivity. Urothelial and renal cancers displayed moderate to strong membranous and cytoplasmic positivity. A majority of malignant gliomas and endometrial cancers were negative.
GENE INFORMATION
Gene name
UPK3B (HGNC Symbol)
Synonyms
FLJ32198, MGC10902, p35, UPIIIb
Description
Uroplakin 3B (HGNC Symbol)
Entrez gene summary
UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[supplied by OMIM, Mar 2008]
