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IL10RB

GENERAL INFORMATION

Gene name

 IL10RB

Gene description

 Interleukin 10 receptor, beta

Protein class

 CD markers
Disease related genes
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 2 antibodies.
HPA047550 , CAB020670
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 IL10RB (HGNC Symbol)

Synonyms

 CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2

Description

 Interleukin 10 receptor, beta (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]

Chromosome

 21

Cytoband

 q22.11

Chromosome location (bp)

 33266358 - 33297234

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000243646 (version 83.38)

Entrez gene

 3588

UniProt

 Q08334 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08334

Antibodypedia

 IL10RB antibodies

PROTEIN BROWSER
IL10RB-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL10RB-001
ENSP00000290200
ENST00000290200
Q08334 [Direct mapping]
Interleukin-10 receptor subunit beta
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Show all
GO:0004872 [receptor activity]
GO:0004920 [interleukin-10 receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032002 [interleukin-28 receptor complex]
GO:0051607 [defense response to virus]
GO:0070062 [extracellular exosome]
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 325 aa
37 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.