Fields »
ABOUT
HELP
BLOG
LEFTY1

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 LEFTY1

Gene description

 Left-right determination factor 1

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (NTERA-2)

Protein evidence

 Evidence at transcript level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 LEFTY1 (HGNC Symbol)

Synonyms

 LEFTB, LEFTYB

Description

 Left-right determination factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q42.12

Chromosome location (bp)

 225886282 - 225911382

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000243709 (version 83.38)

Entrez gene

 10637

UniProt

 O75610 (UniProt - Evidence at transcript level)

neXtProt

 NX_O75610

Antibodypedia

 LEFTY1 antibodies

PROTEIN BROWSER
LEFTY1-001
LEFTY1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LEFTY1-001
ENSP00000272134
ENST00000272134
O75610 [Direct mapping]
Left-right determination factor 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003007 [heart morphogenesis]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007368 [determination of left/right symmetry]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016049 [cell growth]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
Show all
 366 aa
40.9 kDa 		Yes 0
LEFTY1-002
ENSP00000479837
ENST00000492457
A0A087WW09 [Direct mapping]
Left-right determination factor 1
Show all
Predicted intracellular proteins
Show all
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016049 [cell growth]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
Show all
 64 aa
7.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.