Expression of P2RY11 in cancer - Summary

CANCER ATLAS

Gene description

Purinergic receptor P2Y, G-protein coupled, 11

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014232

GENE INFORMATION
Gene name	P2RY11 (HGNC Symbol)
Synonyms	P2Y11
Description	Purinergic receptor P2Y, G-protein coupled, 11 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	10111538 - 10115372
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000244165 (version 83.38)
Entrez gene	5032
UniProt	Q96G91 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96G91
Antibodypedia	P2RY11 antibodies

PROTEIN BROWSER

P2RY11-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
P2RY11-001 ENSP00000323872 ENST00000321826	Q96G91 [Direct mapping] P2Y purinoceptor 11 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001973 [adenosine receptor signaling pathway] GO:0004872 [receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006952 [defense response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0019722 [calcium-mediated signaling] GO:0023041 [neuronal signal transduction] GO:0030594 [neurotransmitter receptor activity] GO:0035589 [G-protein coupled purinergic nucleotide receptor signaling pathway] GO:0045028 [G-protein coupled purinergic nucleotide receptor activity] GO:0045031 [ATP-activated adenosine receptor activity] GO:0071318 [cellular response to ATP] Show all	374 aa 40.3 kDa	No	7