Cell atlas - APOBEC3C - The Human Protein Atlas

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APOBEC3C

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Intermediate filaments

Human cell
	Intermediate Filaments

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GENERAL INFORMATION
Gene name	APOBEC3C
Gene description	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the intermediate filaments.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Intermediate filaments (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA071523
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the intermediate filaments.

Main location

Intermediate filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071523	PC-3	Intermediate filaments
	HPA071523	U-2 OS	Intermediate filaments

GENE INFORMATION
Gene name	APOBEC3C (HGNC Symbol)
Synonyms	APOBEC1L, ARDC2, ARDC4, ARP5, bK150C2.3, PBI
Description	Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C (HGNC Symbol)
Entrez gene summary	This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	39014083 - 39020352
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000244509 (version 83.38)
Entrez gene	27350
UniProt	Q9NRW3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRW3
Antibodypedia	APOBEC3C antibodies

PROTEIN BROWSER

APOBEC3C-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOBEC3C-001 ENSP00000355340 ENST00000361441	Q9NRW3 [Direct mapping] DNA dC->dU-editing enzyme APOBEC-3C Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0009972 [cytidine deamination] GO:0010529 [negative regulation of transposition] GO:0016032 [viral process] GO:0016787 [hydrolase activity] GO:0016814 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines] GO:0044822 [poly(A) RNA binding] GO:0045071 [negative regulation of viral genome replication] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0080111 [DNA demethylation] Show all	190 aa 22.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.