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Most renal cancers along with a fraction of cells in a few cases of endometrial, ovarian and colorectal cancers showed moderate to strong membranous staining with distinct extracellular positivity. Remaining cancer cells were mainly negative.
GENE INFORMATION
Gene name
OR2AE1 (HGNC Symbol)
Synonyms
OR2AE2
Description
Olfactory receptor, family 2, subfamily AE, member 1 (HGNC Symbol)
Entrez gene summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
