Cell atlas - C4A - The Human Protein Atlas

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C4A

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	C4A
Gene description	Complement component 4A (Rodgers blood group)
Protein class	Blood group antigen proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (HDLM-2, U-266/84, U-266/70)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HDLM-2, U-266/84, U-266/70) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	C4A (HGNC Symbol)
Synonyms	C4, C4A2, C4A3, C4A4, C4A6, C4B, C4S, CO4, CPAMD2, RG
Description	Complement component 4A (Rodgers blood group) (HGNC Symbol)
Entrez gene summary	This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31982024 - 32002681
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000244731 (version 83.38)
Entrez gene	720
UniProt	P0C0L4 (UniProt - Evidence at protein level)
neXtProt	NX_P0C0L4
Antibodypedia	C4A antibodies

PROTEIN BROWSER

C4A-001	C4A-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C4A-001 ENSP00000396688 ENST00000428956	P0C0L4 [Direct mapping] Complement C4-A Complement C4 beta chain Complement C4-A alpha chain C4a anaphylatoxin C4b-A C4d-A Complement C4 gamma chain Show all	Blood group antigen proteins MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001849 [complement component C1q binding] GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0010951 [negative regulation of endopeptidase activity] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] GO:2000427 [positive regulation of apoptotic cell clearance] Show all	1744 aa 192.8 kDa	Yes	0
C4A-013 ENSP00000420212 ENST00000498271	P0C0L4 [Direct mapping] Complement C4-A Complement C4 beta chain Complement C4-A alpha chain C4a anaphylatoxin C4b-A C4d-A Complement C4 gamma chain Show all	Blood group antigen proteins MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0001849 [complement component C1q binding] GO:0004866 [endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006956 [complement activation] GO:0006958 [complement activation, classical pathway] GO:0010951 [negative regulation of endopeptidase activity] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] GO:2000427 [positive regulation of apoptotic cell clearance] Show all	1698 aa 187.7 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.