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N4BP2L2

GENERAL INFORMATION

Gene name

 N4BP2L2

Gene description

 NEDD4 binding protein 2-like 2

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic staining in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA039338 , HPA039434
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 N4BP2L2 (HGNC Symbol)

Synonyms

 CG005, PFAAP5

Description

 NEDD4 binding protein 2-like 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 13

Cytoband

 q13.1

Chromosome location (bp)

 32432417 - 32538885

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000244754 (version 83.38)

Entrez gene

 10443

UniProt

 Q92802 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92802

Antibodypedia

 N4BP2L2 antibodies

PROTEIN BROWSER
N4BP2L2-001
N4BP2L2-004
N4BP2L2-005
N4BP2L2-011
N4BP2L2-201
N4BP2L2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
N4BP2L2-001
ENSP00000267068
ENST00000267068
Q92802 [Direct mapping]
NEDD4-binding protein 2-like 2
A0A024RDV2 [Target identity:100%; Query identity:100%]
HCG32190, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0017053 [transcriptional repressor complex]
GO:0019899 [enzyme binding]
GO:0070062 [extracellular exosome]
GO:1902035 [positive regulation of hematopoietic stem cell proliferation]
GO:1902037 [negative regulation of hematopoietic stem cell differentiation]
Show all
 583 aa
67.5 kDa 		No 0
N4BP2L2-004
ENSP00000427477
ENST00000504114
B4DPY1 [Direct mapping]
NEDD4-binding protein 2-like 2; cDNA FLJ55497
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 737 aa
85.4 kDa 		Yes 0
N4BP2L2-005
ENSP00000423362
ENST00000505213
D6R968 [Direct mapping]
NEDD4-binding protein 2-like 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 709 aa
82.4 kDa 		No 0
N4BP2L2-011
ENSP00000394239
ENST00000446957
Q92802 [Direct mapping]
NEDD4-binding protein 2-like 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0017053 [transcriptional repressor complex]
GO:0019899 [enzyme binding]
GO:0070062 [extracellular exosome]
GO:1902035 [positive regulation of hematopoietic stem cell proliferation]
GO:1902037 [negative regulation of hematopoietic stem cell differentiation]
Show all
 655 aa
76.1 kDa 		No 0
N4BP2L2-201
ENSP00000350104
ENST00000357505
B4DPY1 [Direct mapping]
NEDD4-binding protein 2-like 2; cDNA FLJ55497
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 737 aa
85.4 kDa 		Yes 0
N4BP2L2-202
ENSP00000382328
ENST00000399396
Q92802 [Direct mapping]
NEDD4-binding protein 2-like 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0017053 [transcriptional repressor complex]
GO:0019899 [enzyme binding]
GO:0070062 [extracellular exosome]
GO:1902035 [positive regulation of hematopoietic stem cell proliferation]
GO:1902037 [negative regulation of hematopoietic stem cell differentiation]
Show all
 752 aa
87.2 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.