Expression of H2AFJ in cancer - Summary

CANCER ATLAS

Gene description

H2A histone family, member J

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041189

GENE INFORMATION
Gene name	H2AFJ (HGNC Symbol)
Synonyms	FLJ10903, MGC921
Description	H2A histone family, member J (HGNC Symbol)
Entrez gene summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is located on chromosome 12 and encodes a replication-independent histone that is a variant H2A histone. The protein is divergent at the C-terminus compared to the consensus H2A histone family member. This gene also encodes an antimicrobial peptide with antibacterial and antifungal activity.[provided by RefSeq, Oct 2015]
Chromosome	12
Cytoband	p12.3
Chromosome location (bp)	14774383 - 14778002
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000246705 (version 83.38)
Entrez gene	55766
UniProt	Q9BTM1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BTM1
Antibodypedia	H2AFJ antibodies

PROTEIN BROWSER

H2AFJ-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
H2AFJ-001 ENSP00000438553 ENST00000544848	Q9BTM1 [Direct mapping] Histone H2A.J A0A024RAS2 [Target identity:100%; Query identity:100%] Histone H2A Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Show all	GO:0000786 [nucleosome] GO:0000790 [nuclear chromatin] GO:0003674 [molecular_function] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006325 [chromatin organization] GO:0006342 [chromatin silencing] GO:0008150 [biological_process] GO:0046982 [protein heterodimerization activity] GO:0070062 [extracellular exosome] Show all	129 aa 14 kDa	No	0