Expression of INSL3 in cancer - Summary

CANCER ATLAS

Gene description

Insulin-like 3 (Leydig cell)

Protein class

Disease related genes, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028615

GENE INFORMATION
Gene name	INSL3 (HGNC Symbol)
Synonyms	MGC119818, MGC119819, RLF, RLNL
Description	Insulin-like 3 (Leydig cell) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	17816512 - 17821574
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000248099 (version 83.38)
Entrez gene	3640
UniProt	P51460 (UniProt - Evidence at protein level)
neXtProt	NX_P51460
Antibodypedia	INSL3 antibodies

PROTEIN BROWSER

INSL3-001	INSL3-002	INSL3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INSL3-001 ENSP00000321724 ENST00000317306	P51460 [Direct mapping] Insulin-like 3 Insulin-like 3 B chain Insulin-like 3 A chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0002020 [protease binding] GO:0005102 [receptor binding] GO:0005158 [insulin receptor binding] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0007267 [cell-cell signaling] GO:0007283 [spermatogenesis] GO:0010634 [positive regulation of epithelial cell migration] GO:0090303 [positive regulation of wound healing] Show all	131 aa 14.5 kDa	Yes	0
INSL3-002 ENSP00000369017 ENST00000379695	P51460 [Direct mapping] Insulin-like 3 Insulin-like 3 B chain Insulin-like 3 A chain Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0001556 [oocyte maturation] GO:0001664 [G-protein coupled receptor binding] GO:0001701 [in utero embryonic development] GO:0002020 [protease binding] GO:0005102 [receptor binding] GO:0005158 [insulin receptor binding] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] GO:0007283 [spermatogenesis] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008584 [male gonad development] GO:0010634 [positive regulation of epithelial cell migration] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0043066 [negative regulation of apoptotic process] GO:0048471 [perinuclear region of cytoplasm] GO:0090303 [positive regulation of wound healing] Show all	157 aa 16.9 kDa	Yes	0
INSL3-003 ENSP00000469309 ENST00000598577	M0QXQ3 [Direct mapping] Insulin-like 3 Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	71 aa 7.6 kDa	Yes	0