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FMN1

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GENERAL INFORMATION

Gene name

 FMN1

Gene description

 Formin 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Cell line enhanced (RH-30, T-47d, SK-MEL-30)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA046786
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RH-30, T-47d, SK-MEL-30)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (supported)

Additional location

 Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA046786 RH-30 Nucleoplasm
Cytosol
HPA046786 U-2 OS No staining    
HPA046786 U-251 MG No staining    

GENE INFORMATION

Gene name

 FMN1 (HGNC Symbol)

Synonyms

 DKFZP686C2281, FLJ45135, FMN, LD, MGC125288, MGC125289

Description

 Formin 1 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the formin homology family and encodes a protein that has a role in the formation of adherens junction and the polymerization of linear actin cables. The homologous gene in mouse is associated with limb deformity. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

Chromosome

 15

Cytoband

 q13.3

Chromosome location (bp)

 32765545 - 33194733

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000248905 (version 83.38)

Entrez gene

 342184

UniProt

 Q68DA7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q68DA7

Antibodypedia

 FMN1 antibodies

PROTEIN BROWSER
FMN1-001
FMN1-002
FMN1-003
FMN1-004
FMN1-005
FMN1-008
FMN1-009
FMN1-011
FMN1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FMN1-001
ENSP00000333950
ENST00000334528
Q68DA7 [Direct mapping]
Formin-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0045010 [actin nucleation]
Show all
 1196 aa
132.2 kDa 		No 0
FMN1-002
ENSP00000452984
ENST00000558197
Q68DA7 [Direct mapping]
Formin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0045010 [actin nucleation]
Show all
 503 aa
53.6 kDa 		No 0
FMN1-003
ENSP00000453443
ENST00000561249
H0YM30 [Direct mapping]
Formin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005884 [actin filament]
GO:0008017 [microtubule binding]
GO:0045010 [actin nucleation]
Show all
 1321 aa
146.5 kDa 		No 0
FMN1-004
ENSP00000325166
ENST00000320930
Q68DA7 [Direct mapping]
Formin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0045010 [actin nucleation]
Show all
 662 aa
71.9 kDa 		No 0
FMN1-005
ENSP00000454047
ENST00000559047
Q68DA7 [Direct mapping]
Formin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0045010 [actin nucleation]
Show all
 1419 aa
157.6 kDa 		No 0
FMN1-008
ENSP00000453266
ENST00000560317
H0YLM7 [Direct mapping]
Formin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005884 [actin filament]
GO:0008017 [microtubule binding]
GO:0045010 [actin nucleation]
Show all
 181 aa
20.6 kDa 		No 0
FMN1-009
ENSP00000453682
ENST00000558711
H0YMP0 [Direct mapping]
Formin-1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 58 aa
6.5 kDa 		No 0
FMN1-011
ENSP00000453110
ENST00000559610
H0YL93 [Direct mapping]
Formin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 114 aa
13 kDa 		No 0
FMN1-201
ENSP00000479134
ENST00000616417
Q68DA7 [Direct mapping]
Formin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0008017 [microtubule binding]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0017124 [SH3 domain binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0035136 [forelimb morphogenesis]
GO:0035137 [hindlimb morphogenesis]
GO:0045010 [actin nucleation]
GO:0048705 [skeletal system morphogenesis]
GO:0048813 [dendrite morphogenesis]
GO:0051127 [positive regulation of actin nucleation]
GO:0051894 [positive regulation of focal adhesion assembly]
GO:0060173 [limb development]
GO:0072092 [ureteric bud invasion]
Show all
 1419 aa
157.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.