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PDCD6

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GENERAL INFORMATION

Gene name

 PDCD6

Gene description

 Programmed cell death 6

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

Mouse

 Localized to the Cytosol in mouse cells.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA047221
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol.

Main location

 Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA047221 HeLa Cytosol
HPA047221 PC-3 Nucleoplasm
Cytosol Intensity
HPA047221 U-2 OS Cytosol

MOUSE CELLS

Main location

 Cytosol

Mouse gene

 ENSMUSG00000021576 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA047221 NIH 3T3 Cytosol

GENE INFORMATION

Gene name

 PDCD6 (HGNC Symbol)

Synonyms

 ALG-2, PEF1B

Description

 Programmed cell death 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]

Chromosome

 5

Cytoband

 p15.33

Chromosome location (bp)

 271621 - 353856

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000249915 (version 83.38)

Entrez gene

 10016

UniProt

 O75340 (UniProt - Evidence at protein level)

neXtProt

 NX_O75340

Antibodypedia

 PDCD6 antibodies

PROTEIN BROWSER
PDCD6-001
PDCD6-006
PDCD6-008
PDCD6-011
PDCD6-012
PDCD6-201
PDCD6-202
PDCD6-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDCD6-001
ENSP00000264933
ENST00000264933
O75340 [Direct mapping]
Programmed cell death protein 6
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006508 [proteolysis]
GO:0006886 [intracellular protein transport]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031410 [cytoplasmic vesicle]
GO:0031965 [nuclear membrane]
GO:0032007 [negative regulation of TOR signaling]
GO:0034605 [cellular response to heat]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043495 [protein anchor]
GO:0045766 [positive regulation of angiogenesis]
GO:0046983 [protein dimerization activity]
GO:0048306 [calcium-dependent protein binding]
GO:0051592 [response to calcium ion]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060090 [binding, bridging]
GO:0070062 [extracellular exosome]
GO:0070971 [endoplasmic reticulum exit site]
GO:0097190 [apoptotic signaling pathway]
Show all
 191 aa
21.9 kDa 		No 0
PDCD6-006
ENSP00000422691
ENST00000509581
Q86W51 [Direct mapping]
PDCD6 protein; Programmed cell death protein 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0006508 [proteolysis]
Show all
 55 aa
5.7 kDa 		No 0
PDCD6-008
ENSP00000423815
ENST00000507528
O75340 [Direct mapping]
Programmed cell death protein 6
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006508 [proteolysis]
GO:0006886 [intracellular protein transport]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031410 [cytoplasmic vesicle]
GO:0031965 [nuclear membrane]
GO:0032007 [negative regulation of TOR signaling]
GO:0034605 [cellular response to heat]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0042802 [identical protein binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043495 [protein anchor]
GO:0045766 [positive regulation of angiogenesis]
GO:0046983 [protein dimerization activity]
GO:0048306 [calcium-dependent protein binding]
GO:0051592 [response to calcium ion]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060090 [binding, bridging]
GO:0070062 [extracellular exosome]
GO:0070971 [endoplasmic reticulum exit site]
GO:0097190 [apoptotic signaling pathway]
Show all
 189 aa
21.7 kDa 		No 0
PDCD6-011
ENSP00000422085
ENST00000505221
O75340 [Direct mapping]
Programmed cell death protein 6
Show all
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006508 [proteolysis]
GO:0006886 [intracellular protein transport]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0030948 [negative regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0031410 [cytoplasmic vesicle]
GO:0031965 [nuclear membrane]
GO:0032007 [negative regulation of TOR signaling]
GO:0034605 [cellular response to heat]
GO:0036324 [vascular endothelial growth factor receptor-2 signaling pathway]
GO:0042802 [identical protein binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043495 [protein anchor]
GO:0045766 [positive regulation of angiogenesis]
GO:0046983 [protein dimerization activity]
GO:0048306 [calcium-dependent protein binding]
GO:0051592 [response to calcium ion]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060090 [binding, bridging]
GO:0070062 [extracellular exosome]
GO:0070971 [endoplasmic reticulum exit site]
GO:0097190 [apoptotic signaling pathway]
Show all
 69 aa
7.3 kDa 		No 0
PDCD6-012
ENSP00000425370
ENST00000507473
H0Y9X3 [Direct mapping]
Programmed cell death protein 6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0006508 [proteolysis]
Show all
 104 aa
12.2 kDa 		No 0
PDCD6-201
ENSP00000485024
ENST00000614778
A0A024QZ42 [Direct mapping]
HCG1985580, isoform CRA_c; Programmed cell death protein 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0006508 [proteolysis]
Show all
 121 aa
14.5 kDa 		No 0
PDCD6-202
ENSP00000482332
ENST00000618970
A0A087WZ38 [Direct mapping]
Programmed cell death protein 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0006508 [proteolysis]
Show all
 123 aa
14 kDa 		No 0
PDCD6-203
ENSP00000485941
ENST00000628729
D6RA21 [Direct mapping]
Programmed cell death protein 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0006508 [proteolysis]
Show all
 39 aa
4.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.