Expression of CHCHD10 in cancer - Summary

CANCER ATLAS

Gene description

Coiled-coil-helix-coiled-coil-helix domain containing 10

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA003440

GENE INFORMATION
Gene name	CHCHD10 (HGNC Symbol)
Synonyms	C22orf16, N27C7-4
Description	Coiled-coil-helix-coiled-coil-helix domain containing 10 (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial protein that is enriched at cristae junctions in the intermembrane space. It may play a role in cristae morphology maintenance or oxidative phosphorylation. Mutations in this gene cause frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7 and 19. [provided by RefSeq, Aug 2014]
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	23765834 - 23768443
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000250479 (version 83.38)
Entrez gene	400916
UniProt	Q8WYQ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WYQ3
Antibodypedia	CHCHD10 antibodies

PROTEIN BROWSER

CHCHD10-001	CHCHD10-002	CHCHD10-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHCHD10-001 ENSP00000418428 ENST00000484558	Q8WYQ3 [Direct mapping] Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005739 [mitochondrion] GO:0005758 [mitochondrial intermembrane space] GO:0006119 [oxidative phosphorylation] GO:0006754 [ATP biosynthetic process] GO:0007005 [mitochondrion organization] GO:2000984 [negative regulation of ATP citrate synthase activity] Show all	142 aa 14.1 kDa	No	0
CHCHD10-002 ENSP00000384973 ENST00000401675	B5MBW9 [Direct mapping] Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 14.9 kDa	No	0
CHCHD10-005 ENSP00000430042 ENST00000520222	E5RH03 [Direct mapping] Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		55 aa 5.8 kDa	No	0