Expression of SEPP1 in cancer - Summary

CANCER ATLAS

Gene description

Selenoprotein P, plasma, 1

Protein class

Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036287

GENE INFORMATION
Gene name	SEPP1 (HGNC Symbol)
Synonyms	SelP, SeP, SEPP
Description	Selenoprotein P, plasma, 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	p12
Chromosome location (bp)	42799880 - 42887392
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000250722 (version 83.38)
Entrez gene	6414
UniProt	P49908 (UniProt - Evidence at protein level)
neXtProt	NX_P49908
Antibodypedia	SEPP1 antibodies

PROTEIN BROWSER

SEPP1-001	SEPP1-002	SEPP1-004	SEPP1-005	SEPP1-006	SEPP1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEPP1-001 ENSP00000420939 ENST00000514985	P49908 [Direct mapping] Selenoprotein P Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001887 [selenium compound metabolic process] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006979 [response to oxidative stress] GO:0007420 [brain development] GO:0007626 [locomotory behavior] GO:0008430 [selenium binding] GO:0009791 [post-embryonic development] GO:0019953 [sexual reproduction] GO:0040007 [growth] GO:0070062 [extracellular exosome] Show all	381 aa 43.2 kDa	Yes	0
SEPP1-002 ENSP00000427671 ENST00000511224	P49908 [Direct mapping] Selenoprotein P Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006979 [response to oxidative stress] GO:0070062 [extracellular exosome] Show all	381 aa 43.2 kDa	Yes	0
SEPP1-004 ENSP00000425915 ENST00000506577	P49908 [Direct mapping] Selenoprotein P Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006979 [response to oxidative stress] GO:0070062 [extracellular exosome] Show all	381 aa 43.2 kDa	Yes	0
SEPP1-005 ENSP00000421626 ENST00000514218	D6REX5 [Direct mapping] Selenoprotein P Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		310 aa 35.2 kDa	Yes	0
SEPP1-006 ENSP00000427414 ENST00000510965	D6RIS9 [Direct mapping] Selenoprotein P Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		209 aa 23.7 kDa	Yes	0
SEPP1-012 ENSP00000473340 ENST00000507920	R4GMT5 [Direct mapping] Selenoprotein P Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	171 aa 19.4 kDa	Yes	3