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Moderate to strong cytoplasmic positivity was observed in several carcinoids, hepatocellular carcinomas and renal cancers along with a few malignant gliomas, colorectal, skin, pancreatic and endometrial cancers. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
PRODH2 (HGNC Symbol)
Synonyms
HSPOX1
Description
Proline dehydrogenase (oxidase) 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is similar to proline dehydrogenase (oxidase) 1, a mitochondrial enzyme which catalyzes the first step in proline catabolism. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004657 [proline dehydrogenase activity] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0010133 [proline catabolic process to glutamate] GO:0055114 [oxidation-reduction process]
