Cell atlas - PCDHGB1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

PCDHGB1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Focal adhesion sites
	Midbody
	Plasma membrane

Human cell
	Actin Filaments
	Microtubules
	Plasma Membrane

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	PCDHGB1
Gene description	Protocadherin gamma subfamily B, 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane, midbody & focal adhesion sites.
RNA cell category	Cell line enhanced (T-47d, ASC TERT1)
Protein evidence	Evidence at transcript level
Main location	Localized to the Plasma membrane (approved), Focal adhesion sites (approved), Midbody (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA076182
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane, midbody & focal adhesion sites.

Main location

Plasma membrane (approved), Focal adhesion sites (approved), Midbody (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA076182	A549	Midbody	Intensity	Intensity
	HPA076182	MCF7	Midbody	Intensity	Intensity
	HPA076182	U-2 OS	Plasma membrane
	HPA076182	U-2 OS	Focal adhesion sites

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition

GENE INFORMATION
Gene name	PCDHGB1 (HGNC Symbol)
Synonyms	PCDH-GAMMA-B1
Description	Protocadherin gamma subfamily B, 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	141350102 - 141512979
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000254221 (version 83.38)
Entrez gene	56104
UniProt	Q9Y5G3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9Y5G3
Antibodypedia	PCDHGB1 antibodies

PROTEIN BROWSER

PCDHGB1-001	PCDHGB1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCDHGB1-001 ENSP00000429273 ENST00000523390	Q9Y5G3 [Direct mapping] Protocadherin gamma-B1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030426 [growth cone] Show all	927 aa 100.4 kDa	Yes	1
PCDHGB1-002 ENSP00000478900 ENST00000611598	Q9Y5G3 [Direct mapping] Protocadherin gamma-B1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	810 aa 88.2 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.