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CHMP4A

GENERAL INFORMATION

Gene name

 CHMP4A

Gene description

 Charged multivesicular body protein 4A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression, including membranous expression in several different cell types.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA068473
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin020406080100120140TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin05101520RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0102030405060Tags Per Million

GENE INFORMATION

Gene name

 CHMP4A (HGNC Symbol)

Synonyms

 C14orf123, HSPC134, VPS32A

Description

 Charged multivesicular body protein 4A (HGNC Symbol)

Entrez gene summary

 CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

Chromosome

 14

Cytoband

 q12

Chromosome location (bp)

 24209583 - 24213869

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000254505 (version 83.38)

Entrez gene

 29082

UniProt

 Q9BY43 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BY43

Antibodypedia

 CHMP4A antibodies

PROTEIN BROWSER
CHMP4A-001
CHMP4A-004
CHMP4A-009
CHMP4A-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHMP4A-001
ENSP00000324205
ENST00000347519
Q9BY43 [Direct mapping]
Charged multivesicular body protein 4a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000815 [ESCRT III complex]
GO:0000920 [cell separation after cytokinesis]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006620 [posttranslational protein targeting to membrane]
GO:0006900 [membrane budding]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007080 [mitotic metaphase plate congression]
GO:0008289 [lipid binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010324 [membrane invagination]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0030117 [membrane coat]
GO:0030496 [midbody]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031902 [late endosome membrane]
GO:0039702 [viral budding via host ESCRT complex]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0051117 [ATPase binding]
GO:0051258 [protein polymerization]
GO:0051260 [protein homooligomerization]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0097320 [membrane tubulation]
GO:1901215 [negative regulation of neuron death]
GO:1902902 [negative regulation of autophagosome assembly]
Show all
 265 aa
29.8 kDa 		No 0
CHMP4A-004
ENSP00000449757
ENST00000530996
H0YIN6 [Direct mapping]
Charged multivesicular body protein 4a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005622 [intracellular]
GO:0007034 [vacuolar transport]
Show all
 117 aa
13.1 kDa 		No 0
CHMP4A-009
ENSP00000432575
ENST00000533011
E9PQ80 [Direct mapping]
Charged multivesicular body protein 4a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0007034 [vacuolar transport]
Show all
 213 aa
24.2 kDa 		No 0
CHMP4A-012
ENSP00000476412
ENST00000609024
Q9BY43 [Direct mapping]
Charged multivesicular body protein 4a
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000815 [ESCRT III complex]
GO:0000920 [cell separation after cytokinesis]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006620 [posttranslational protein targeting to membrane]
GO:0006900 [membrane budding]
GO:0006997 [nucleus organization]
GO:0007034 [vacuolar transport]
GO:0007080 [mitotic metaphase plate congression]
GO:0008289 [lipid binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010324 [membrane invagination]
GO:0016032 [viral process]
GO:0016197 [endosomal transport]
GO:0019058 [viral life cycle]
GO:0030117 [membrane coat]
GO:0030496 [midbody]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031902 [late endosome membrane]
GO:0039702 [viral budding via host ESCRT complex]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0051117 [ATPase binding]
GO:0051258 [protein polymerization]
GO:0051260 [protein homooligomerization]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0097320 [membrane tubulation]
GO:1901215 [negative regulation of neuron death]
GO:1902902 [negative regulation of autophagosome assembly]
Show all
 222 aa
25.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.