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DYX1C1

GENERAL INFORMATION

Gene name

 DYX1C1

Gene description

 Dyslexia susceptibility 1 candidate 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Tissue enhanced (thyroid gland, testis)
FANTOM5:Tissue enhanced (pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA051048
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pituitary gland)

GENE INFORMATION

Gene name

 DYX1C1 (HGNC Symbol)

Synonyms

 CILD25, DNAAF4, EKN1, FLJ37882

Description

 Dyslexia susceptibility 1 candidate 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene. [provided by RefSeq, Mar 2011]

Chromosome

 15

Cytoband

 q21.3

Chromosome location (bp)

 55410525 - 55508234

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000256061 (version 83.38)

Entrez gene

 161582

UniProt

 Q8WXU2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WXU2

Antibodypedia

 DYX1C1 antibodies

PROTEIN BROWSER
DYX1C1-001
DYX1C1-002
DYX1C1-003
DYX1C1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DYX1C1-001
ENSP00000323275
ENST00000321149
Q8WXU2 [Direct mapping]
Dyslexia susceptibility 1 candidate gene 1 protein
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0001764 [neuron migration]
GO:0003341 [cilium movement]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007368 [determination of left/right symmetry]
GO:0030331 [estrogen receptor binding]
GO:0033146 [regulation of intracellular estrogen receptor signaling pathway]
GO:0036158 [outer dynein arm assembly]
GO:0036159 [inner dynein arm assembly]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 420 aa
48.5 kDa 		No 0
DYX1C1-002
ENSP00000402640
ENST00000457155
Q8WXU2 [Direct mapping]
Dyslexia susceptibility 1 candidate gene 1 protein
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0001764 [neuron migration]
GO:0003341 [cilium movement]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007368 [determination of left/right symmetry]
GO:0030331 [estrogen receptor binding]
GO:0033146 [regulation of intracellular estrogen receptor signaling pathway]
GO:0036158 [outer dynein arm assembly]
GO:0036159 [inner dynein arm assembly]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 376 aa
44 kDa 		No 0
DYX1C1-003
ENSP00000403412
ENST00000448430
Q8WXU2 [Direct mapping]
Dyslexia susceptibility 1 candidate gene 1 protein
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0001764 [neuron migration]
GO:0003341 [cilium movement]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007368 [determination of left/right symmetry]
GO:0030331 [estrogen receptor binding]
GO:0033146 [regulation of intracellular estrogen receptor signaling pathway]
GO:0036158 [outer dynein arm assembly]
GO:0036159 [inner dynein arm assembly]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 381 aa
44.2 kDa 		No 0
DYX1C1-201
ENSP00000299561
ENST00000348518
Q8WXU2 [Direct mapping]
Dyslexia susceptibility 1 candidate gene 1 protein
Show all
Predicted intracellular proteins
Disease related genes
Show all
GO:0001764 [neuron migration]
GO:0003341 [cilium movement]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007368 [determination of left/right symmetry]
GO:0030331 [estrogen receptor binding]
GO:0033146 [regulation of intracellular estrogen receptor signaling pathway]
GO:0036158 [outer dynein arm assembly]
GO:0036159 [inner dynein arm assembly]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 420 aa
48.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.