Cell atlas - TEN1 - The Human Protein Atlas

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TEN1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TEN1
Gene description	TEN1 CST complex subunit
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA065069
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA065069	PC-3	Nucleoplasm
	HPA065069	SH-SY5Y	Nucleus
	HPA065069	U-2 OS	Nucleus

GENE INFORMATION
Gene name	TEN1 (HGNC Symbol)
Synonyms	C17orf106, FLJ39785
Description	TEN1 CST complex subunit (HGNC Symbol)
Entrez gene summary	C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]
Chromosome	17
Cytoband	q25.1
Chromosome location (bp)	75979220 - 76000586
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000257949 (version 83.38)
Entrez gene	100134934
UniProt	Q86WV5 (UniProt - Evidence at protein level)
neXtProt	NX_Q86WV5
Antibodypedia	TEN1 antibodies

PROTEIN BROWSER

TEN1-001	TEN1-002	TEN1-003	TEN1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TEN1-001 ENSP00000380762 ENST00000397640	Q86WV5 [Direct mapping] CST complex subunit TEN1 Show all	Predicted intracellular proteins Show all	GO:0000784 [nuclear chromosome, telomeric region] GO:0003697 [single-stranded DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0010521 [telomerase inhibitor activity] GO:0042162 [telomeric DNA binding] GO:0051974 [negative regulation of telomerase activity] GO:0070188 [Stn1-Ten1 complex] GO:1904356 [regulation of telomere maintenance via telomere lengthening] Show all	123 aa 13.9 kDa	No	0
TEN1-002 ENSP00000465299 ENST00000590676	K7EJS2 [Direct mapping] CST complex subunit TEN1 Show all	Predicted intracellular proteins Show all	GO:0003697 [single-stranded DNA binding] GO:0070188 [Stn1-Ten1 complex] Show all	56 aa 6.3 kDa	No	0
TEN1-003 ENSP00000464792 ENST00000586891	K7EIL0 [Direct mapping] CST complex subunit TEN1 Show all	Predicted intracellular proteins Show all	GO:0003697 [single-stranded DNA binding] GO:0070188 [Stn1-Ten1 complex] Show all	101 aa 11.5 kDa	No	0
TEN1-005 ENSP00000465866 ENST00000588202	K7EL09 [Direct mapping] CST complex subunit TEN1 Show all	Predicted intracellular proteins Show all	GO:0003697 [single-stranded DNA binding] GO:0070188 [Stn1-Ten1 complex] Show all	73 aa 8.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.