Cell atlas - TRIM34 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TRIM34
Gene description	Tripartite motif containing 34
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the centrosome. In addition localized to the nucleoli. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Centrosome (approved)
Additional location	In addition localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA077996
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the centrosome. In addition localized to the nucleoli. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Centrosome (approved)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA077996	A549	Nucleoli
HPA077996	A549	Centrosome
HPA077996	REH	Centrosome
HPA077996	U-2 OS	Centrosome

GENE INFORMATION
Gene name	TRIM34 (HGNC Symbol)
Synonyms	RNF21
Description	Tripartite motif containing 34 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	5619764 - 5644398
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000258659 (version 83.38)
Entrez gene	53840
UniProt	Q9BYJ4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BYJ4
Antibodypedia	TRIM34 antibodies

PROTEIN BROWSER

TRIM34-001	TRIM34-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRIM34-001 ENSP00000402595 ENST00000429814	Q9BYJ4 [Direct mapping] Tripartite motif-containing protein 34 Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0008270 [zinc ion binding] GO:0019221 [cytokine-mediated signaling pathway] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070206 [protein trimerization] Show all	488 aa 56.9 kDa	No	0
TRIM34-003 ENSP00000422947 ENST00000514226	Q9BYJ4 [Direct mapping] Tripartite motif-containing protein 34 Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0008270 [zinc ion binding] GO:0019221 [cytokine-mediated signaling pathway] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0070206 [protein trimerization] Show all	488 aa 56.9 kDa	No	0