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Several cases of most cancers displayed weak to moderate cytoplasmic positivity with additional nuclear or membranous staining in a few cases. Endometrial, carcinoids, gliomas, lymphomas and testicular cancers were mainly negative.
GENE INFORMATION
Gene name
DUXA
Synonyms
Description
Double homeobox A (HGNC Symbol)
Entrez gene summary
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DUXA homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]